R5155

Rocuronium -bromid

≥97% (perchloric acid titration)

• Synonym(e): (+)-Rocuronium bromide
• Empirische Formel (Hill-System): C₃₂H₅₃BrN₂O₄
• CAS-Nummer: 119302-91-9
• Molekulargewicht: 609.68
• NACRES: NA.77
• PubChem Substance ID: 329824032
• UNSPSC Code: 51152000
• MDL number: MFCD00867768

Eigenschaften

• Quality Segment: 100
• assay: ≥97% (perchloric acid titration)
• form: powder
• functional group: ester
• shipped in: ambient
• storage temp.: room temp
• SMILES string: [Br-].CC(=O)O[C@H]1[C@H](C[C@H]2[C@@H]3CC[C@H]4C[C@H](O)[C@H](C[C@]4(C)[C@H]3CC[C@]12C)N5CCOCC5)[N+]6(CCCC6)CC=C
• InChI: 1S/C32H53N2O4.BrH/c1-5-14-34(15-6-7-16-34)28-20-26-24-9-8-23-19-29(36)27(33-12-17-37-18-13-33)21-32(23,4)25(24)10-11-31(26,3)30(28)38-22(2)35;/h5,23-30,36H,1,6-21H2,2-4H3;1H/q+1;/p-1/t23-,24+,25-,26-,27-,28-,29-,30-,31-,32-;/m0./s1
• InChI key: OYTJKRAYGYRUJK-FMCCZJBLSA-M
• Gene Information: human ... CHRNA1(1134), CHRNB1(1140), CHRND(1144), CHRNE(1145), CHRNG(1146)

Beschreibung

Biochem/physiol Actions

Aminosteroid; neuromuskulärer Blocker für Anästhesie

Rocuronium Bromide is a fumarate, non-depolarizing, neuromuscular blocking agent. It is rapid-acting, relaxes the skeletal muscle and decreases oxygen consumption during surgery. It competes with acetylcholine and bind to cholinergic receptors at neuromuscular junctions.[1][2]

Preparation Note

Rocuronium bromide yields clear, light yellow solution in water at 100 mg/ml.

Sicherheitshinweise

• pictograms: GHS06
• signalword: Danger
• hcodes: H301,H335
• pcodes: P261 - P264 - P271 - P301 + P310 - P304 + P340 + P312 - P403 + P233
• Hazard Classifications: Acute Tox. 3 Oral - STOT SE 3
• target_organs: Respiratory system
• Lagerklasse: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)