R4155

Anti-hnRNP-E1/E2 (N-terminal) antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution

• Synonym(e): Anti-HNRPE1/HNRPE2, Anti-Heterogeneous nuclear ribonucleoprotein E1/E2, Anti-PCBP1/PCBP2, Anti-poly(rC) binding protein 1 /protein 2
• UNSPSC-Code: 12352203
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: rabbit
• Konjugat: unconjugated
• Antikörperform: affinity isolated antibody
• Antikörper-Produkttyp: primary antibodies
• Klon: polyclonal
• Form: buffered aqueous solution
• Mol-Gew.: antigen ~37 kDa
• Speziesreaktivität: human, rat, mouse
• Verpackung: antibody small pack of 25 μL
• Konzentration: ~1.0 mg/mL
• Methode(n): immunoprecipitation (IP): 5-10 μg using K562 cell extract; western blot: 0.5-1 μg/mL using K562 cell extract
• UniProt-Hinterlegungsnummer: Q15365
• Versandbedingung: dry ice
• Lagertemp.: −20°C
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... PCBP1(5093) ; mouse ... Pcbp1(23983) ; rat ... Pcbp1(500242)

Beschreibung

Allgemeine Beschreibung

hnRNP-E1/E2 (heterogeneous nuclear ribonucleoproteins) belongs to hnRNP (heterogeneous ribonucleoprotein) family. It is also known as poly-C binding proteins (PCBP) 1 and 2. It is located on chromosome 2p13. PCBP1 gene has no intron and codes for a 356 amino acid poly (rC) binding protein 1, that is of 35kDa. It has three K-Homology (KH) domains and two nuclear localization signals.

Anwendung

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)

Biochem./physiol. Wirkung

hnRNP-E1/E2 (heterogeneous nuclear ribonucleoproteins) participates in the development and progression of tumor. It is involved in several transcriptional and posttranscriptional events like mRNA transcription regulation, transportation, splicing, translation, and stabilization. It plays critical roles in cancer apoptosis, metastasis, invasion and malignant transformation. It may also participates in epithelial-mesenchymal transition (EMT).

Physikalische Form

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: nwg
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)