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Merck

P9511

Sigma-Aldrich

3-sn-Phosphatidsäure Natriumsalz aus Eigelb-Lecithin

≥98%

Synonym(e):

L-α-Phosphatidsäure Natriumsalz, PA

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About This Item

MDL-Nummer:
UNSPSC-Code:
12352106
PubChem Substanz-ID:
NACRES:
NA.77

Assay

≥98%

Form

powder

Lagertemp.

−20°C

SMILES String

[Na+].[Na+].OC[C@@H](O)COP([O-])([O-])=O

InChI

1S/C3H9O6P.2Na/c4-1-3(5)2-9-10(6,7)8;;/h3-5H,1-2H2,(H2,6,7,8);;/q;2*+1/p-2/t3-;;/m1../s1

InChIKey

GEKBIENFFVFKRG-HWYNEVGZSA-L

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Allgemeine Beschreibung

Phosphatidic acid is obtained from phosphatidylcholine with the help of phospholipase D.

Anwendung

3-sn-Phosphatidic acid sodium salt from egg yolk lecithin
  • in the reaction mixture for CDS (cytidine triphosphate:phosphatidate cytidyltransferase) assay and reference lipid for thin layer chromatography (TLC)
  • as a standard to compare the generated radiolabeled phosphatidic acid (PA)
  • to examine its effects on At-Rac2–associated kinase activity

Biochem./physiol. Wirkung

Phosphatidic acid might serve as a modulator of phagocyte respiratory burst. It also acts as a precursor of diacylglycerol, phosphatidic acid and lysophosphatidic acid.

Leistungsmerkmale und Vorteile

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Phosphodiesterases, Phosphoinositide Kinases and Phosphoprotein Phosphatases (Serine/Threonine) pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Angaben zur Herstellung

Prepared from L-α-phosphatidylcholine by hydrolysis with cabbage phospholipase D.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)


Analysenzertifikate (COA)

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Die Dokumentenbibliothek aufrufen

Complementary DNAs encoding eukaryotic-type cytidine-5 [prime]-diphosphate-diacylglycerol synthases of two plant species
Kopka J, et al.
Plant Physiology, 113(3), 997-1002 (1997)
Glycerolipids in signal transduction
Lambeth JD, et al.
New Biotechnology, 31, 237-255 (1996)
Rac homologues and compartmentalized phosphatidylinositol 4, 5-bisphosphate act in a common pathway to regulate polar pollen tube growth
Kost B, et al.
The Journal of cell biology, 145(2), 317-330 (1999)
Stefano Mancuso et al.
Plant signaling & behavior, 2(4), 240-244 (2007-07-01)
Auxin (IAA) is versatile signalling molecule of plants, currently classified as plant hormone. But there are data suggesting that auxin is acting also as plant-specific morphogen, electric-responses inducing transmitter, and as general signalling molecule used for plant-bacteria communication. Our previous
Phosphatidic acid and phospholipase D both stimulate phosphoinositide turnover in cultured human keratinocytes
Ryder NS, et al.
Cellular Signalling, 5(6), 787-794 (1993)

Artikel

Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.

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