P7265

Prostaglandin A₁

≥98% (HPLC), powder, NF-κB inhibitor

• Synonym(e): (13E,15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-säure, PGA₁
• Empirische Formel (Hill-System): C₂₀H₃₂O₄
• CAS-Nummer: 14152-28-4
• Molekulargewicht: 336.47
• NACRES: NA.77
• PubChem Substance ID: 24898834
• UNSPSC Code: 12352211
• MDL number: MFCD00077858
• Beilstein/REAXYS Number: 2003401
• Assay: ≥98%
• Form: powder

Eigenschaften

• Produktname: Prostaglandin A₁, synthetic
• biological source: synthetic
• Quality Segment: 200
• assay: ≥98%
• form: powder
• storage temp.: −20°C
• SMILES string: O=C1[C@H](CCCCCCC(O)=O)[C@@H](/C=C/[C@H](CCCCC)O)C=C1
• InChI: 1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-18,21H,2-11H2,1H3,(H,23,24)/b14-12+/t16-,17-,18+/m0/s1
• InChI key: BGKHCLZFGPIKKU-LDDQNKHRSA-N

Beschreibung

Biochem/physiol Actions

Prostaglandin A1 (PGA1) is a cyclopentenone prostaglandin containing chemically reactive α,β-unsaturated carbonyl. This cyclooxygenase 2 (COX-2) metabolic product aids in regulating the development and progression of Alzheimer′s disease (AD). In addition, PGA1 also regulates various biological processes via Michael addition. It exhibits antiviral activity against avian influenza A viruses (IAV) by inducing cytoprotective heat shock response in infected cells and by inhibiting nuclear factor-κB (NF-κB) activity.

Sicherheitshinweise

• pictograms: GHS08,GHS07
• signalword: Danger
• hcodes: H302,H360F
• pcodes: P201 - P301 + P312 + P330 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Oral - Repr. 1B
• Lagerklasse: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)