Prepared solutions are stable up to 2 months when stored at -20℃. Note that frozen stock solutions may have a precipitate upon thawing. Gentle shaking or brief sonication of the solution will typically dissolve the precipitate. Stock solutions are also stable at 2 - 8℃ when protected from light. Please see the link below to review additional information available in the datasheet for P0409, the non-irradiated version of this product:
https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/documents/407/849/p0409pis.pdf
Fortfahren mit
P6532
Prostaglandin E2
γ-irradiated, powder, BioXtra, suitable for cell culture
Synonym(e):
(5Z,11α,13E,15S)-11,15-Dihydroxy-9-oxoprosta-5,13-diensäure, Dinoproston, PGE2
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| Ihnen/SKU | Verfügbarkeit | Preis |
|---|---|---|
1 mg | Warenkorb auf Verfügbarkeit prüfen | € 528,00 |
Über diesen Artikel
Empirische Formel (Hill-System):
C20H32O5
CAS-Nummer:
Molekulargewicht:
352.47
NACRES:
NA.77
PubChem Substance ID:
eCl@ss:
42020658
UNSPSC Code:
12352209
EC Number:
206-656-6
MDL number:
Beilstein/REAXYS Number:
4709356
Biological source:
synthetic (organic)
Form:
powder
Technischer Dienst
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Unterstützung erhaltenbiological source
synthetic (organic)
Quality Segment
sterility
γ-irradiated
product line
BioXtra
form
powder
potency
0.25-100 ng/mL
technique(s)
cell culture | mammalian: suitable
solubility
ethanol: 1 mg/mL
shipped in
ambient
storage temp.
−20°C
SMILES string
O[C@@H]1CC([C@H](C/C=C\CCCC(O)=O)[C@H]1/C=C/[C@@H](O)CCCCC)=O
InChI
1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1
InChI key
XEYBRNLFEZDVAW-ARSRFYASSA-N
Gene Information
human ... PTGER1(5731), PTGER2(5732), PTGER3(5733), PTGER4(5734), PTGIR(5739)
mouse ... Ptger1(19216), Ptger2(19217), Ptger3(19218), Ptger4(19219)
Application
Prostaglandin E2 wurde verwendet, um seine Auswirkungen auf die durch die Alveolarzellkarzinom-Zelllinie A549 vermittelte Kollagengel-Kontraktion zu bestimmen.
Zur Verwendung in Zellkulturanwendungen für die Untersuchung der Prostaglandin-regulierten zellulären Signalgebung und Genregulierung.
Biochem/physiol Actions
Biologisch aktivstes Prostaglandin.
Most biologically active prostaglandin. PGE2 induces cervical ripening and parturition; mediates bradykinin-induced vasodilation; regulates adenylyl cyclase. Tumor cells that over-express cyclooxygenase 2 display increased invasiveness, angiogenesis, and resistance to apoptosis that may be due to the PGE2-induced expression of angiogenic factors and stabilization of the anti-apoptotic protein, survivin.
The effect of PGE2 on the immune system is mixed. It inhibits T cell activation in vitro, suggesting it is an immunosuppressant. However, in vivo, it appears to effect expansion of the Th17 subset and differentiation of the Th1 subset of T helper cells, marking it as an immunoactivator.
The effect of PGE2 on the immune system is mixed. It inhibits T cell activation in vitro, suggesting it is an immunosuppressant. However, in vivo, it appears to effect expansion of the Th17 subset and differentiation of the Th1 subset of T helper cells, marking it as an immunoactivator.
Physical form
Pulver -20 °C; in Arbeitsaliquote aufgeteilt eingefroren, wiederholtes Einfrieren und Auftauen vermeiden
1 of 1
Dieser Artikel | |||
|---|---|---|---|
| biological source synthetic (organic) | biological source synthetic | biological source synthetic | biological source - |
| Quality Level 200 | Quality Level 200 | Quality Level 200 | Quality Level 100 |
| product line BioXtra | product line BioReagent | product line - | product line - |
| form powder | form powder | form powder | form solid |
| technique(s) cell culture | mammalian: suitable | technique(s) cell culture | mammalian: suitable | technique(s) - | technique(s) - |
| Gene Information human ... PTGER1(5731), PTGER2(5732), PTGER3(5733), PTGER4(5734), PTGIR(5739) | Gene Information human ... PTGER1(5731), PTGER2(5732), PTGER3(5733), PTGER4(5734), PTGIR(5739) | Gene Information human ... PTGER1(5731), PTGER2(5732), PTGER3(5733), PTGER4(5734), PTGIR(5739) | Gene Information - |
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signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Repr. 1B
Lagerklasse
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
ppe
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
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Once reconstituted, how long can aliquots be stored at -20℃?
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