P4904

Platelet Activating Factor-16

≥98%, pro-inflammatory lipid mediator, powder

• Synonym(e): β-Acetyl-γ-O-Hexadecyl-L-α-Phosphatidylcholin, PAF, Platelet Activating Factor
• Empirische Formel (Hill-System): C₂₆H₅₄NO₇P · xH₂O
• CAS-Nummer: 74389-68-7
• Molekulargewicht: 523.68 (anhydrous basis)
• UNSPSC Code: 12352211
• PubChem Substance ID: 24898570
• NACRES: NA.77
• Beilstein/REAXYS Number: 3574588
• MDL number: MFCD00150679
• Assay: ≥98%
• Form: powder

Eigenschaften

• Produktname: 2-Acetyl-1-hexadecyl-sn-glycero-3-phosphorylcholin Hydrat, ≥98%
• Quality Segment: 200
• assay: ≥98%
• form: powder
• storage temp.: −20°C
• SMILES string: O.CCCCCCCCCCCCCCCCOC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(C)=O
• InChI: 1S/C26H54NO7P.H2O/c1-6-7-8-9-10-11-12-13-14-15-16-17-18-19-21-31-23-26(34-25(2)28)24-33-35(29,30)32-22-20-27(3,4)5;/h26H,6-24H2,1-5H3;1H2/t26-;/m1./s1
• InChI key: HFMSDOHEENWULV-UFTMZEDQSA-N

Beschreibung

Application

β-Acetyl-γ-O-hexadecyl-L-α-phosphatidylcholine has been used:

• to study its effects on phagocytic activity and production of superoxide anion in equine alveolar macrophage and blood neutrophils[1]
• to study its protective effects against cisplatin-induced cell death in a human melanoma cell line in vitro[2]
• to determine its effects on cervical ripening and leukocyte infiltration in rat models[3]

Biochem/physiol Actions

β-Acetyl-γ-O-hexadecyl-L-α-phosphatidylcholine or platelet-activating factor (PAF), is a phospholipid[4], and a pro-inflammatory lipid mediator.[5] It acts as a ligand for G protein-coupled platelet-activating factor (PAF) receptors and participates in several biological processes such as airway constriction, hypotension, platelet activation, and increased vascular permeability.[5] PAF is released by various cells such as platelets, neutrophils, endothelial cells, and monocytes/macrophages. The levels of PAF are low in the blood due to its rapid metabolism by PAF acetylhydrolase and low production.[6]

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)