P4157

Phe-Arg β-naphthylamide dihydrochloride

cathepsin substrate, fluorogenic, ≥98% (TLC), powder

• Synonym(e): PAβN
• Empirische Formel (Hill-System): C₂₅H₃₀N₆O₂ · 2HCl
• CAS-Nummer: 100929-99-5
• Molekulargewicht: 519.47
• UNSPSC Code: 12352204
• PubChem Substance ID: 24898508
• NACRES: NA.32
• MDL number: MFCD00058046

Eigenschaften

• Produktname: Phe-Arg β-naphthylamide dihydrochloride, cathepsin substrate
• Quality Segment: 200
• assay: ≥98% (TLC)
• form: powder
• solubility: water: 50 mg/mL, clear, colorless to faintly yellow
• storage temp.: −20°C
• SMILES string: Cl.NC(Cc1ccccc1)C(=O)NC(CCCNC(N)=N)C(=O)Nc2ccc3ccccc3c2
• InChI: 1S/C25H30N6O2.ClH/c26-21(15-17-7-2-1-3-8-17)23(32)31-22(11-6-14-29-25(27)28)24(33)30-20-13-12-18-9-4-5-10-19(18)16-20;/h1-5,7-10,12-13,16,21-22H,6,11,14-15,26H2,(H,30,33)(H,31,32)(H4,27,28,29);1H
• InChI key: ZMTAZQYLEGNUTJ-UHFFFAOYSA-N

Beschreibung

General description

Substrate for dipeptidyl aminopeptidase I (cathepsin C).

Phe-Arg β-naphthylamide, a peptidomimetic compound,[1] is an efflux pump inhibitor (EPI). It acts on the major multidrug resistance efflux transporters of Gram-negative bacteria. Phe-Arg -naphthylamide lowers fluoroquinolone resistance in Pseudomonas aeruginosa.[1]

Application

Phe-Arg -naphthylamide dihydrochloride has been used to evaluate the contribution of efflux pumps to antimicrobial resistance. It has also been used for minimal inhibitory concentration testing in the presence of an efflux pump inhibitor.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)