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P201

R(−)-PD 128,908 hydrochloride

Name: R(−)-PD 128,908 hydrochloride
Brand: SIGMA

>97%, solid

Synonym(e):

R(–)-(4aS,10bS)-3,4,4a,10b-Tetrahydro-4-propyl-2H,5H-[1]benzopyrano-[4,3-b]-1,4-oxazin-9-ol

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About This Item

Empirische Formel (Hill-System):

C₁₄H₁₉NO₃ · HCl

Molekulargewicht:

285.77

MDL-Nummer:

MFCD00210210

UNSPSC-Code:

41106305

PubChem Substanz-ID:

24898264

Assay

>97%

Form

solid

Optische Aktivität

[α]21/D −67.2°, c = 0.1 in methanol(lit.)

Farbe

white

Löslichkeit

ethanol: >10 mg/mL
DMSO: 18 mg/mL
H₂O: 9 mg/mL

SMILES String

Cl[H].CCCN1CCO[C@H]2[C@H]1COc3ccc(O)cc23

InChI

1S/C14H19NO3.ClH/c1-2-5-15-6-7-17-14-11-8-10(16)3-4-13(11)18-9-12(14)15;/h3-4,8,12,14,16H,2,5-7,9H2,1H3;1H/t12-,14-;/m1./s1

InChIKey

DCFXOTRONMKUJB-QMDUSEKHSA-N

Biochem./physiol. Wirkung

Selective D₃ dopamine receptor agonist; less active enantiomer of S(+)-PD 128,907 hydrochloride.

Vorsicht

Light sensitive.

Rechtliche Hinweise

Manufactured and sold with the permission of Warner-Lambert Company.

Lagerklassenschlüssel

13 - Non Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

Analysenzertifikate (COA)

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Assessment of cocaine-like discriminative stimulus effects of dopamine D₃ receptor ligands.

Acri, et al.

European Journal of Pharmacology, 281 (1995)

A functional test identifies dopamine agonists selective for D3 versus D2 receptors.

F Sautel et al.

Neuroreport, 6(2), 329-332 (1995-01-26)

The functional potency of a series of dopamine agonists for increasing mitogenesis, measured by incorporation of [3H]thymidine, was established in transfected cell lines expressing human D2 or D3 receptors. The functional selectivity of agonists markedly differs from their binding selectivity.

Synthesis and dopamine agonist properties of (+-)-trans-3,4,4a,10b-tetrahydro-4-propyl-2H,5H-[1]benzopyrano [4,3-b]-1,4-oxazin-9-ol and its enantiomers.

H A DeWald et al.

Journal of medicinal chemistry, 33(1), 445-450 (1990-01-01)

The dopamine agonist profile of (+-)-trans-3,4,4a,10b-tetrahydro-4-propyl-2H,5H-[1]benzopyrano [4,3-b]-1,4-oxazin-9-ol (16a) and its enantiomers (16b-c) was examined. Racemic 16a exhibited moderate affinity for the dopamine (DA) D2 receptor labeled with the DA antagonist ligand [3H]haloperidol and moderate in vivo activity; it attenuated gamma-butyrolactone-stimulated

Chemical genetics reveals a complex functional ground state of neural stem cells.

Phedias Diamandis et al.

Nature chemical biology, 3(5), 268-273 (2007-04-10)

The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain cancer. However, the complete repertoire of signaling pathways that governs the

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