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P0248

Sigma-Aldrich

PNU-37883A

≥98% (HPLC), powder

Synonym(e):

N-(1-Adamantyl)-N′-cyclohexyl-4-morpholinecarboxamidine hydrochloride

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About This Item

Empirische Formel (Hill-System):
C21H36ClN3O
CAS-Nummer:
57568-80-6
Molekulargewicht:
381.98
MDL-Nummer:
MFCD06798347
UNSPSC-Code:
12352200
PubChem Substanz-ID:
24277692

Assay

≥98% (HPLC)

Form

powder

Farbe

white

Löslichkeit

DMSO: ~23 mg/mL
H2O: insoluble

Lagertemp.

2-8°C

SMILES String

Cl.C1CCC(CC1)\N=C(/NC23CC4CC(CC(C4)C2)C3)N5CCOCC5

Angaben zum Gen

human ... KCNJ8(3764)

Biochem./physiol. Wirkung

Selective inhibitor of Kir6.1/SUR2B channels.

Lagerklassenschlüssel

13 - Non Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

Analysenzertifikate (COA)

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H Kovalev et al.
British journal of pharmacology, 141(5), 867-873 (2004-02-06)
1. In this study, we have used Kir6.1/Kir6.2 chimeric proteins and current recordings to investigate the molecular basis of PNU-37883A inhibition of cloned K(ATP) channels. 2. Rat Kir6.1, Kir6.2 and Kir6.1/Kir6.2 chimeras were co-expressed with either SUR2B or SUR1, following
Bobby D Nossaman et al.
Journal of cardiovascular pharmacology, 50(4), 358-366 (2007-12-01)
The free radical peroxynitrite (ONOO-) is formed in biological systems from the reaction of nitric oxide (NO) with superoxide (O2-) and can react with protein and nonprotein thiol groups to produce tissue injury. However, these pathologic actions of (ONOO-) may
Mariko Yamanaka et al.
International immunopharmacology, 2(13-14), 1957-1964 (2002-12-20)
It is suggested that attenuation of the renal kallikrein-kinin system (KKS) involved the development of hypertension in young spontaneously hypertensive rats (SHR). In the present study, a comparison was made between young SHR and Wistar Kyoto rats (WKY) to examine
Salma Toma Hanna et al.
European journal of pharmacology, 515(1-3), 34-42 (2005-05-17)
Kir6.1 subunit is one of the pore-forming components of K(ATP) channel complex. The endogenous modulation of Kir6.1 subunit function has been largely unknown. Whether acetylcholine modulated the function of Kir6.1 subunit stably expressed in human embryonic kidney (HEK-293) cells was
Noriyoshi Teramoto et al.
European journal of pharmacology, 506(1), 1-7 (2004-12-14)
Kinetic studies of U-37883A (4-morpholinecarboximidine-N-1-adamantyl-N'-cyclohexyl-hydrochloride), a vascular ATP-sensitive K+ channel (KATP channel) blocker, were performed on pig urethral myocytes to investigate inhibitory effects on large-conductance intracellular Ca2+ -sensitive K+ channels (i.e., BKCa channels; 225 pS K+ channels) by use of
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