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P0034

20S-Protopanaxatriol

Synonym(e):

20(S)-APPT, g-PPT

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Über diesen Artikel

Empirische Formel (Hill-System):
C30H52O4
CAS-Nummer:
Molekulargewicht:
476.73
UNSPSC Code:
12352200
MDL number:
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form

powder

Quality Level

storage temp.

2-8°C

InChI

1S/C30H52O4/c1-18(2)10-9-13-30(8,34)19-11-15-28(6)24(19)20(31)16-22-27(5)14-12-23(33)26(3,4)25(27)21(32)17-29(22,28)7/h10,19-25,31-34H,9,11-17H2,1-8H3/t19-,20+,21-,22+,23-,24-,25-,27+,28-,29+,30-/m0/s1

InChI key

SHCBCKBYTHZQGZ-PHFGEWBZSA-N

General description

A ginsenoside metabolite that has been linked to endothelial cell function via the glucocortoid receptor (GR) and the oestrogen receptor (ER).

Application

20S-Protopanaxatriol (g-PPT), a dammarane-type tetracyclic terpene sapogenin, may be used to study its binding to and modulation of cell function via glucocortoid (GR) and oestrogen (ER) receptors.

Biochem/physiol Actions

A metabolites of ginsenoside, protopanaxatriol (g-PPT), could modulate endothelial cell functions through the glucocorticoid receptor (GR) and oestrogen receptor (ER).

Lagerklasse

12 - Non Combustible Liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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Estrogens exert many of their behavioral effects by binding to nuclear estrogen receptor (ER) proteins, ERalpha and ERbeta. Recent studies involving ER knockout mice and selective ER agonists suggest that estradiol's anorexigenic effect is mediated via activation of ERalpha. To
Haiping Hao et al.
Drug metabolism and disposition: the biological fate of chemicals, 38(10), 1731-1739 (2010-07-20)
Although the biotransformation of ginsenosides in the gastrointestinal tract has been extensively studied, much less is known about hepatic cytochrome P450 (P450)-catalyzed metabolism. The major aims of this study were to clarify the metabolic pathway and P450 isoforms involved and
Ya-Jun He et al.
Phytotherapy research : PTR, 27(4), 628-632 (2012-06-28)
Ginseng, a commonly used natural product, has been frequently reported to induce herb-drug interaction with many clinical drugs. The intestinal bacterial metabolites of ginsenosides have been widely regarded as the substance basis for ginseng-drug interactions. To date, little is known
Guo-Yuan Zhu et al.
Journal of agricultural and food chemistry, 59(1), 200-205 (2010-12-15)
Ginseng, the root of Panax ginseng C. A. Meyer (Araliaceae), is one of the most important traditional medicines and functional foods. A detailed phytochemical investigation on the roots of P. ginseng led to the isolation of 6 new natural protopanaxatriol

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