P0028

PSN-375963

≥98% (HPLC)

• Synonym(e): 4-[5-(4-butylcyclohexyl)-1,2,4-oxadiazol-3-yl]-pyridine
• Empirische Formel (Hill-System): C₁₇H₂₃N₃O
• CAS-Nummer: 388575-52-8
• Molekulargewicht: 285.38
• NACRES: NA.77
• PubChem Substance ID: 329819983
• UNSPSC Code: 12352202
• MDL number: MFCD01829706
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• assay: ≥98% (HPLC)
• form: powder
• color: white to off-white
• solubility: DMSO: >10 mg/mL
• storage temp.: −20°C
• SMILES string: CCCCC1CCC(CC1)c2nc(no2)-c3ccncc3
• InChI: 1S/C17H23N3O/c1-2-3-4-13-5-7-15(8-6-13)17-19-16(20-21-17)14-9-11-18-12-10-14/h9-13,15H,2-8H2,1H3
• InChI key: OAVLEYPTWABFLF-UHFFFAOYSA-N

Beschreibung

Biochem/physiol Actions

PSN-375963 is a GPR119 partial agonist.

PSN-375963 is a GPR119 partial agonist. GPR119 is an orphan GPCR, expressed predominantly in pancreas and GI tract, that has been characterized. Its endogenous ligands are oleoylethanolamide (OEA) and oleoyl-lysophosphatidylcholine, lipid signaling molecules that regulate food intake and body weight. OEA decreases food intake, so GPR119 agonists are potential therapies for obesity. Initial studies showed that PSN-375963 has similar potency and partial efficacy compared to OEA. Further studies revealed that although OEA and PSN-375963 are GPR119 agonists, they have divergent effects on insulin secretion, calcium signaling, and cAMP production.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: nwg
• flash_point_f: Not applicable
• flash_point_c: Not applicable