P0018

Pomalidomide

≥98% (HPLC), powder, HbF inducer

• Synonym(e): 1,3-dioxo-2-(2,6-dioxopiperidin-3-yl)-4-aminoisoindoline, 3-amino-N-(2,6-dioxo-3-piperidyl)phthalamide, 4-Amino-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione, Actimid, CC-4047, IMiD 3
• Empirische Formel (Hill-System): C₁₃H₁₁N₃O₄
• CAS-Nummer: 19171-19-8
• Molekulargewicht: 273.24
• UNSPSC Code: 12352200
• PubChem Substance ID: 329819974
• NACRES: NA.77
• MDL number: MFCD12756407
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• Produktname: Pomalidomide, ≥98% (HPLC)
• ligand: pomalidomide
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• reaction suitability: reagent type: ligand
• color: yellow
• solubility: DMSO: ≥14 mg/mL
• storage temp.: 2-8°C
• SMILES string: Nc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12
• InChI: 1S/C13H11N3O4/c14-7-3-1-2-6-10(7)13(20)16(12(6)19)8-4-5-9(17)15-11(8)18/h1-3,8H,4-5,14H2,(H,15,17,18)
• InChI key: UVSMNLNDYGZFPF-UHFFFAOYSA-N
• Gene Information: human ... CRBN(51185), CUL4A(8451), DDB1(1642), RBX1(9978)

Beschreibung

Application

Pomalidomide has been used:

• to treat BV173 cells to study the role of proteolysis targeting chimera (PROTAC) compound, JQ1-CRBN, in inducing specific class-I major histocompatibility complex (MHC-I) peptides[1]
• for apoptosis studies and intracellular calcium analysis[2]
• as a fetal hemoglobin (HbF) agent to study the additive effect with UNC0638 on the levels of fetal hemoglobin expression in β-thalassemia/ variant hemoglobin E (HbE) erythroid progenitor cells[3]

Biochem/physiol Actions

Pomalidomide is a second generation immunomodulator, TNF-α inhibitor, and thalidomide analog.

Pomalidomide is an effective fetal hemoglobin (HbF) inducer that downregulates the key &#947-globin repressors, SRY-box transcription factor 6 (SOX6), and BAF chromatin remodeling complex subunit (BCL11A).[3]

Features and Benefits

This compound is featured on the Cytokine Receptors (Tumor Necrosis Receptor Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Sicherheitshinweise

• pictograms: GHS08
• signalword: Danger
• hcodes: H360D
• pcodes: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Repr. 1B
• Lagerklasse: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable