N8784
Norcantharidin
solid
Anmelden zur Ansicht der Organisations- und Vertragspreise.
Über diesen Artikel
Empirische Formel (Hill-System):
C8H8O4
CAS-Nummer:
Molekulargewicht:
168.15
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352202
MDL number:
Form:
solid
Fortfahren mit
Technischer Dienst
Benötigen Sie Hilfe? Unser Team von erfahrenen Wissenschaftlern ist für Sie da.
Unterstützung erhaltenInChI
1S/C8H8O4/c9-7-5-3-1-2-4(11-3)6(5)8(10)12-7/h3-6H,1-2H2
SMILES string
O=C1OC(=O)C2C3CCC(O3)C12
InChI key
JAABVEXCGCXWRR-UHFFFAOYSA-N
form
solid
Gene Information
human ... PPP2R5A(5525)
General description
Norcantharidin (NCTD) is a demethylated derivative of cantharidin (CTD).
Application
Norcantharidin has been used in primary cell culture and treatment. It has also been used to treat mice inoculated with Huh7 cells subcutaneously.[1]
Biochem/physiol Actions
Norcantharidin is a potential antitumor agent. Norcantharidin helps to block SK-N-SH neuroblastoma cell growth by stimulating autophagy and apoptosis.
Lagerklasse
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Hier finden Sie alle aktuellen Versionen:
Besitzen Sie dieses Produkt bereits?
In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.
Xin-Yuan Ding et al.
International journal of nanomedicine, 7, 1723-1735 (2012-05-24)
A novel formulation containing polyvinylpyrrolidone (PVP) K(30)-coated norcantharidin (NCTD) chitosan nanoparticles (PVP-NCTD-NPs) was prepared by ionic gelation between chitosan and sodium tripolyphosphate. The average particle size of the PVP-NCTD-NPs produced was 140.03 ± 6.23 nm; entrapment efficiency was 56.33% ±
Novel norcantharidin-loaded liver targeting chitosan nanoparticles to enhance intestinal absorption.
Yong-yan Bei et al.
International journal of nanomedicine, 7, 1819-1827 (2012-05-24)
In this paper, two novel liver-targeting nanoparticles, norcantharidin-loaded chitosan nanoparticles (NCTD-CS-NPs) and norcantharidin-associated galactosylated chitosan nanoparticles (NCTD-GC-NPs), were prepared using ionic cross-linkage. The physical properties, particle size, encapsulation efficiency, and drug release characteristics of the nanoparticles were investigated in vitro.
Min Guan et al.
International journal of nanomedicine, 7, 1921-1930 (2012-05-19)
In this paper, novel liver-targeting nanoparticles (NPs), lactosyl-norcantharidin (Lac-NCTD)-associated N-trimethyl chitosan (TMC) NPs (Lac-NCTD-TMC-NPs), were prepared using ionic cross-linkage. The physical properties, particle size, and encapsulation efficiency of the nanoparticles were then investigated. The continuous line of heterogeneous human epithelial
Yong Li et al.
Frontiers in pharmacology, 11, 187-187 (2020-03-21)
Drug repositioning, development of new uses for marketed drugs, is an effective way to discover new antitumor compounds. In this study, we used a new method, filtering compounds via molecular docking to find key targets combination. The data of gene
Mark Tarleton et al.
European journal of medicinal chemistry, 54, 573-581 (2012-07-17)
Cantharidin (1) and norcantharidin (2) display high levels of anticancer activity against a broad range of tumour cell lines. Synthetic manipulation of norcantharidin yields (3S,3aR,4S,7R,7aS)-3-hydroxyhexahydro-4,7-epoxyisobenzofuran-1(3H)-one (3), which also displays a high level of anticancer activity against tumour cells but interestingly
Active Filters
Unser Team von Wissenschaftlern verfügt über Erfahrung in allen Forschungsbereichen einschließlich Life Science, Materialwissenschaften, chemischer Synthese, Chromatographie, Analytik und vielen mehr..
Setzen Sie sich mit dem technischen Dienst in Verbindung