N4411
NU6027
≥98% (HPLC)
Synonym(e):
4-Cyclohexylmethoxy-2,6-diamino-5-nitrosopyrimidine
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Empirische Formel (Hill-System):
C11H17N5O2
CAS-Nummer:
Molekulargewicht:
251.28
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Technischer Dienst
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Unterstützung erhaltenassay
≥98% (HPLC)
form
solid
color
lavender
mp
252.5-253.7 °C (lit.)
solubility
DMSO: 15 mg/mL
storage temp.
2-8°C
SMILES string
O=NC1=C(N)N=C(N)N=C1OCC2CCCCC2
InChI
1S/C11H17N5O2/c12-9-8(16-17)10(15-11(13)14-9)18-6-7-4-2-1-3-5-7/h7H,1-6H2,(H4,12,13,14,15)
InChI key
DGWXOLHKVGDQLN-UHFFFAOYSA-N
Gene Information
human ... CDK2(1017), MGMT(4255)
Biochem/physiol Actions
NU6027 is a potent inhibitor of ATR signalling
Selective cyclin-dependent kinase-2 (CDK2) inhibitor.
Lagerklasse
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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A Peasland et al.
British journal of cancer, 105(3), 372-381 (2011-07-07)
The ataxia telangiectasia mutated and Rad3-related kinase (ATR) has a key role in the signalling of stalled replication forks and DNA damage to cell cycle checkpoints and DNA repair. It has long been recognised as an important target for cancer
Rebeka Sultana et al.
PloS one, 8(2), e57098-e57098 (2013-03-02)
Ataxia telangiectasia mutated and Rad3 Related (ATR) protein kinase is a key sensor of single-stranded DNA associated with stalled replication forks and repair intermediates generated during DNA repair. XRCC1 is a critical enzyme in single strand break repair and base
Jie Chen et al.
DNA repair, 73, 55-63 (2018-11-25)
The ataxia telangiectasia-mutated and Rad3-related (ATR) serine/threonine kinase plays a central role in the repair of replication-associated DNA damage, the maintenance of S and G2/M-phase genomic stability, and the promotion of faithful mitotic chromosomal segregation. A number of stimuli activate