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N179

Sigma-Aldrich

NS 102

solid

Synonym(e):

6,7,8,9-Tetrahydro-5-nitro-1H-benz[g]indole-2,3-dione 3-oxime

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About This Item

Empirische Formel (Hill-System):
C12H11N3O4
CAS-Nummer:
136623-01-3
Molekulargewicht:
261.23
UNSPSC-Code:
12352200
PubChem Substanz-ID:
24897529
NACRES:
NA.32

Form

solid

Farbe

yellow

Löslichkeit

DMSO: >3 mg/mL
H2O: insoluble
methanol: insoluble

SMILES String

O\N=C1/C(=O)Nc2c3CCCCc3c(cc12)[N+]([O-])=O

InChI

1S/C12H11N3O4/c16-12-11(14-17)8-5-9(15(18)19)6-3-1-2-4-7(6)10(8)13-12/h5,17H,1-4H2,(H,13,14,16)

InChIKey

SCDBMLHUXJBJSS-UHFFFAOYSA-N

Angaben zum Gen

human ... GRIN1(2902) , GRIN2A(2903) , GRIN2B(2904) , GRIN2C(2905) , GRIN2D(2906) , GRIN3A(116443) , GRIN3B(116444) , GRINA(2907)
mouse ... GRIN1(14810) , GRIN2A(14811) , GRIN2B(14812) , GRIN2C(14813) , GRIN2D(14814) , GRIN3A(242443) , GRIN3B(170483) , GRINA(66168)
rat ... GRIN1(24408) , GRIN2A(24409) , GRIN2B(24410) , GRIN2C(24411) , GRIN2D(24412) , GRIN3A(191573) , GRIN3B(170796) , GRINA(266668)

Biochem./physiol. Wirkung

Competitive glutamate receptor antagonist with high selectivity for the low-affinity [3H] kainate binding site.

Rechtliche Hinweise

Sold under exclusive license from NeuroSearch A/S.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

Analysenzertifikate (COA)

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Toshiaki Minami et al.
British journal of pharmacology, 142(4), 679-688 (2004-05-26)
1. Ingestion of a poisonous mushroom Clitocybe acromelalga is known to cause severe tactile pain (allodynia) in the extremities for a month and acromelic acid (ACRO), a kainate analogue isolated from the mushroom, produces selective damage of interneurons of the
Hubert Monnerie et al.
Journal of neuroscience research, 83(6), 944-956 (2006-02-25)
Glutamate is an important regulator of dendrite development that may inhibit, (during ischemic injury), or facilitate (during early development) dendrite growth. Previous studies have reported mainly on the N-methyl-D-aspartate (NMDA) receptor-mediated dendrite growth-promoting effect of glutamate. In this study, we
T H Johansen et al.
European journal of pharmacology, 246(3), 195-204 (1993-08-15)
5-Nitro-6,7,8,9-tetrahydrobenzo[G]indole-2,3-dione-3-oxime (NS-102), a new competitive glutamate receptor antagonist displaced binding to non-N-methyl-D-aspartate (non-NMDA) binding sites with no activity at the NMDA and strychnine-insensitive glycine binding sites. Under experimental conditions in which both high- and low-affinity sites were labelled, NS-102 only
H Kamiya et al.
The Journal of physiology, 509 ( Pt 3), 833-845 (1998-05-23)
1. The effect of a low concentration (1 microM) of kainate (kainic acid; KA) on presynaptic calcium (Ca2+) influx at the Schaffer collateral-commissural (SCC) synapse was examined in rat hippocampal slices. 2. Following selective loading of the presynaptic terminals with
R A Tasker et al.
Canadian journal of physiology and pharmacology, 74(9), 1047-1054 (1996-09-01)
Our objective was to characterize the neurotoxic actions of systemically administered domoic acid on different excitatory amino acid receptors, and to compare the receptor selectivity of domoate with the related compound kainic acid. Groups of mice were injected with various
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