This product is not an active/mature myostatin protein. The sequence used for this myostatin protein is residues 267 - 375. The recombinant protein also includes an N-terminal His tag followed by a spacer before the myostatin sequence.
M3064
Myostatin human
recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
Synonym(e):
GDF-8, Growth Differentiation Factor - 8
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Biological source:
human
Recombinant:
expressed in E. coli
Assay:
≥95% (SDS-PAGE)
Form:
lyophilized powder
Mol wt:
16 kDa (including a 31 amino-acid spacer and 6-His tag)
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Dieser Artikel | |||
|---|---|---|---|
| recombinant expressed in E. coli | recombinant expressed in CHO cells | recombinant expressed in CHO cells | recombinant expressed in E. coli |
| assay ≥95% (SDS-PAGE) | assay >97% (visualized with silver stain, SDS-PAGE) | assay ≥95% (HPLC), ≥95% (SDS-PAGE) | assay ≥98% (HPLC), ≥98% (SDS-PAGE) |
| technique(s) cell culture | mammalian: suitable | technique(s) cell culture | mammalian: suitable | technique(s) cell culture | mammalian: suitable | technique(s) cell culture | mammalian: suitable |
| biological source human | biological source human | biological source human | biological source human |
| Quality Level 200 | Quality Level 100 | Quality Level - | Quality Level - |
| form lyophilized powder | form lyophilized powder | form lyophilized | form lyophilized |
Application
Use recombinant myostatin to study its mechanisms of action in vitro.
Biochem/physiol Actions
Myostatin is a 25 KDa, homodimer, that acts on muscle to induce SMAD family transcription factors such as SMAD2 and SMAD3. It inhibits the differentiation of myoblasts into mature muscle fibers. Positive control for myostatin in Western blots and ELISA.
Positive control for myostatin in Western blots and ELISA.
Lagerklasse
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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H Takahashi et al.
Domestic animal endocrinology, 48, 62-68 (2014-06-08)
The purpose of this study was to determine whether myostatin alters glucose transporter-4 (GLUT4) expression in bovine skeletal muscles and myoblasts isolated from double-muscled (DM) and normal-muscled (NM) Japanese Shorthorn cattle. Plasma concentrations of glucose were lower in DM cattle
Karima Relizani et al.
Molecular therapy : the journal of the American Society of Gene Therapy, 22(8), 1423-1433 (2014-05-28)
Myostatin regulates skeletal muscle size via the activin receptor IIB (ActRIIB). However, its effect on muscle energy metabolism and energy-dependent muscle function remains largely unexplored. This question needs to be solved urgently since various therapies for neuromuscular diseases based on
Qiang Zhang et al.
The FEBS journal, 277(2), 466-476 (2009-12-18)
The ubiquitin ligase RING finger protein 13 gene (RNF13) was first identified in a screen for genes whose expression is regulated by myostatin in chicken fetal myoblasts. In this study, we demonstrate that the RNF13 gene is broadly expressed in
R E Ferrell et al.
Genomics, 62(2), 203-207 (1999-12-28)
Myostatin is a recently identified member of the transforming growth factor-beta family of regulatory factors, also known as growth and differentiation factor 8 (GDF8). The nucleotide sequence of human myostatin was determined in 40 individuals. The invariant promoter contains a
Yutaka Ohsawa et al.
PloS one, 10(7), e0133713-e0133713 (2015-08-01)
Myostatin, a muscle-specific transforming growth factor-β (TGF-β), negatively regulates skeletal muscle mass. The N-terminal prodomain of myostatin noncovalently binds to and suppresses the C-terminal mature domain (ligand) as an inactive circulating complex. However, which region of the myostatin prodomain is
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Is this the active/mature myostatin protein or does is it the proprotein before being activated?
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