Unfortunately, we do not test any of our products such as M0418 for specific applications. We sell products in small scale for laboratory use and application. The information is based on that Melanin as a small molecule used in Cell culture application. We do not have specific publications or protocols to share.
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M0418
Melanin
Synthetic, BioReagent, suitable for cell culture
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| Packungsgröße | SKU | Verfügbarkeit | Preis |
|---|---|---|---|
| 100 mg | Warenkorb auf Verfügbarkeit prüfen | € 110,00 | |
| 1 g | Warenkorb auf Verfügbarkeit prüfen | € 555,00 |
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Technischer Dienst
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Unterstützung erhaltenbiological source
synthetic
product line
BioReagent
assay
≥85% (TLC)
form
powder
technique(s)
cell culture | mammalian: suitable
solubility
1 N NH4OH: 20 mg/mL
storage temp.
−20°C
SMILES string
[nH]1c2c3c(c4c5c([nH]c4)c([c]([c](c5c3c1)=O)=O)C)[c]([c](c2C)=O)=O
InChI
1S/C18H10N2O4/c1-5-13-9-7(3-19-13)12-10-8(11(9)17(23)15(5)21)4-20-14(10)6(2)16(22)18(12)24/h3-4,19-20H,1-2H3
InChI key
XUMBMVFBXHLACL-UHFFFAOYSA-N
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Dieser Artikel | |||
|---|---|---|---|
| technique(s) cell culture | mammalian: suitable | technique(s) - | technique(s) HPLC: suitable, gas chromatography (GC): suitable | technique(s) - |
| form powder | form powder | form - | form powder |
| solubility 1 N NH4OH: 20 mg/mL | solubility - | solubility - | solubility 3.2 g/L |
| assay ≥97% (TLC) | assay - | assay - | assay - |
| storage temp. −20°C | storage temp. −20°C | storage temp. 2-30°C | storage temp. no temp limit |
| product line BioReagent | product line - | product line - | product line - |
General description
Melanin is a distinctive class of pigment found in animals, plants, bacteria, and fungi. It is an amorphous polymer formed by the polymerization of phenolic and indolic compounds.
Application
Melanin has been used:
- to incubate normal human keratinocytes for Masson-Fontana staining
- as a standard in the determination of melanin content in normal human epidermal melanocytes and immortalized human keratinocytes
- as an absorber to mimic human skin or melanocytic nevi and melanoma
Biochem/physiol Actions
Melanin plays a role in camouflage and energy harvesting. It also helps in protection against ionizing UV radiations, protection against biotic factors such as host defense against pathogens, and abiotic factors like heat, cold and osmotic stress. Melanin acts as a potent cation chelator and is a component of several photoprotective creams as it facilitates free radical scavenging activity. Melanin may be useful as a photo protectant in cell culture.
Preparation Note
Prepared by oxidation of tyrosine with hydrogen peroxide.
Lagerklasse
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Nadine Santana-Magal et al.
Cancer research, 80(10), 1942-1956 (2020-03-05)
The recent success of checkpoint blockade therapies has established immunotherapy as one of the most promising treatments for melanoma. Nonetheless, a complete curative response following immunotherapy is observed only in a fraction of patients. To identify what factors limit the
Michael Waisberg et al.
PloS one, 7(1), e29493-e29493 (2012-01-14)
Malaria has had the largest impact of any infectious disease on shaping the human genome, exerting enormous selective pressure on genes that improve survival in severe malaria infections. Modern humans originated in Africa and lost skin melanization as they migrated
Naira V Margaryan et al.
International journal of molecular sciences, 17(3), 418-418 (2016-03-25)
Expression of Nodal, a Transforming Growth Factor-beta (TGF-β) related growth factor, is associated with aggressive melanoma. Nodal expression in adult dysplastic nevi may predict the development of aggressive melanoma in some patients. A subset of pediatric patients diagnosed with giant
Li Ni-Komatsu et al.
Molecular pharmacology, 74(6), 1576-1586 (2008-09-20)
A series of quinolines, including chloroquine and quinine, were identified as potent pigmentation inhibitors through screening a compound library in murine melanocytes. Structure-activity relationship analysis indicated that 4-substituted amino groups with a tertiary amine side chain, such as chloroquine, were
Global Trade Item Number
| SKU | GTIN |
|---|---|
| M0418-1G | 04061835568796 |
| M0418-100MG | 04061833993132 |
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Is there any pretreatment other than sonication that should be done before adding to cells? Also, please let me know if there are any precedents for such processing.
1 answer-
Helpful?
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I wonder if you can let me know what type of melanin pigment this reagent has. Is it pheo-, eu- or mixed melanin? What is the level of polymerization? Thank you!
1 answer-
This product is synthetic melanin, per Med. Res. Reviews 8 (1988) pp. 525-556, synthetic melanins are "eumelanin type pigments". Unfortunately, no additional information on the level of polymerization is available.
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