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L5022

Sigma-Aldrich

[D-Lys6]-LH-RH

≥95% (HPLC), powder

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About This Item

Empirische Formel (Hill-System):
C59H84N18O13
CAS-Nummer:
52671-12-2
Molekulargewicht:
1253.41
MDL-Nummer:
MFCD00133504
UNSPSC-Code:
12352200
PubChem Substanz-ID:
24896386

Assay

≥95% (HPLC)

Form

powder

UniProt-Hinterlegungsnummer

P01148

Lagertemp.

−20°C

SMILES String

CC(C)CC(NC(=O)C(CCCCN)NC(=O)C(Cc1ccc(O)cc1)NC(=O)C(CO)NC(=O)C(Cc2c[nH]c3ccccc23)NC(=O)C(Cc4cnc[nH]4)NC(=O)C5CCC(=O)N5)C(=O)NC(CCCNC(N)=N)C(=O)N6CCCC6C(=O)NCC(N)=O

Angaben zum Gen

human ... GNRH1(2796)

Amino Acid Sequence

pGlu-His-Trp-Ser-Tyr-D-Lys-Leu-Arg-Pro-Gly-NH2

Biochem./physiol. Wirkung

LH-RH agonist. It has been conjugated to cytotoxic compounds such as methotrexate (MTX), doxorubicin (DOX), and glutaryl-2-(hydroxymethyl)anthraquinone (G-HMAQ), and together with other conjugated LH-RH analogs comprise a class of targeted chemotherapeutic agents for cancers expressing receptors for LH-RH.

Piktogramme

Health hazard
GHS08

Signalwort

Danger

H-Sätze

H360

Gefahreneinstufungen

Repr. 1B

Lagerklassenschlüssel

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

Analysenzertifikate (COA)

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L Jennes et al.
Peptides, 5 Suppl 1, 215-220 (1984-01-01)
The intracellular pathway of an enzyme resistant GnRH agonist (D-Lys6-GnRH) conjugated to ferritin or to colloidal gold was followed in cultured pituitary cells. After an initial uniform distribution over the cell surface of gonadotropes, the electrondense marker was internalized, either
A Jagannadha Rao et al.
Journal of steroid biochemistry, 23(5B), 807-809 (1985-11-01)
A few analogues of LHRH have been tested in the adult bonnet monkeys using change in serum testosterone following LHRH injection as a parameter of response to LHRH. Of the four analogues tested in male monkeys, Buserelin was found to
J Pinski et al.
Cancer, 72(11), 3263-3270 (1993-12-01)
Palliative methods for treatment of advanced prostatic carcinoma, including those based on luteinizing hormone-releasing hormone (LH-RH) agonists, cannot prevent the ultimate growth of hormone-independent cells, and the duration of disease remission in patients with prostate cancer is limited. New therapeutic
Z Rékási et al.
Endocrinology, 132(5), 1991-2000 (1993-05-01)
A novel class of targeted chemotherapeutic agents based on cytotoxic compounds linked to LHRH analogs was tested in a long term superfusion system in order to determine their effects on different types of rat pituitary cells. The compounds investigated included
Alexandra P Kafka et al.
Molecular pharmaceutics, 6(5), 1483-1491 (2009-08-07)
Poly(ethylcyanoacrylate) (PECA) nanoparticles containing the bioactive d-Lys(6)-GnRH were manufactured by an in situ interfacial polymerization process using a w/o-microemulsion template containing the peptide in the dispersed aqueous pseudophase of the microemulsion. Polymeric nanoparticles were characterized using PCS, RP-HPLC (bulk level)
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