K1519

KM11060

≥98% (HPLC)

• Synonym(e): 7-Chloro-4-[4-[4-chlorophenyl)sulfonyl]-1-piperazinyl]quinoline
• Empirische Formel (Hill-System): C₁₉H₁₇Cl₂N₃O₂S
• CAS-Nummer: 774549-97-2
• Molekulargewicht: 422.33
• UNSPSC Code: 12352200
• PubChem Substance ID: 329817126
• MDL number: MFCD01524977

Eigenschaften

• assay: ≥98% (HPLC)
• form: powder
• solubility: DMSO: >10 mg/mL
• storage temp.: room temp
• SMILES string: Clc1ccc(cc1)S(=O)(=O)N2CCN(CC2)c3ccnc4cc(Cl)ccc34
• InChI: 1S/C19H17Cl2N3O2S/c20-14-1-4-16(5-2-14)27(25,26)24-11-9-23(10-12-24)19-7-8-22-18-13-15(21)3-6-17(18)19/h1-8,13H,9-12H2
• InChI key: GIEHIZKCIZLXLF-UHFFFAOYSA-N

Beschreibung

Biochem/physiol Actions

KM11060 is a mutated F508del CFTR corrector.

KM11060 is a mutated F508del cystic fibrosis transmembrane conductance regulator (CFTR) corrector. The most common mutation (~90%) in the CFTR gene is a deletion of phenylalanine 508 (F508del). The mutation impairs folding, trafficking, membrane stability, and channel gating leading to reduced CFTR expression and chloride conductance in the apical membrane and other abnormalities. KM11060 is an analog of sildenafil, which restores a function of the F508del mutated CFTR chloride channel. KM11060 appears to be more potent than sildenafil, forskolin, and genistein.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges