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I7003

Sigma-Aldrich

Ibogain -hydrochlorid

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About This Item

Empirische Formel (Hill-System):
C20H26N2O · HCl
CAS-Nummer:
5934-55-4
Molekulargewicht:
346.89
EG-Nummer:
227-687-1
MDL-Nummer:
MFCD00167426
UNSPSC-Code:
12352200

Arzneimittelkontrolle

USDEA Schedule I; regulated under CDSA - not available from Sigma-Aldrich Canada

Löslichkeit

H2O: soluble
methanol: soluble

Anwendung(en)

forensics and toxicology

SMILES String

Cl.CCC1CC2CC3C1N(CCc4c3[nH]c5ccc(OC)cc45)C2

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Biochem./physiol. Wirkung

Ibogaine is a central nervous system stimulant and hallucinogen that has been reported to be a σ2 agonist, a noncompetitive NMDA receptor antagonist at the phencyclidine site and an enhancer of purinergic muscle contractions. It is also a competitive inhibitor of serotonin and dopamine transport. It is an anti-convulsant and has anti-addictive properties against cocaine and heroin.

Angaben zur Herstellung

Aus dem afrikanischen Strauch Tabernanthe iboga isoliertes Alkaloid.

Piktogramme

Exclamation mark
GHS07

Signalwort

Warning

H-Sätze

H302

Gefahreneinstufungen

Acute Tox. 4 Oral

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Analysenzertifikate (COA)

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Y Itzhak et al.
Annals of the New York Academy of Sciences, 844, 245-251 (1998-07-21)
Although the alkaloid ibogaine is a potent hallucinogenic agent some indications suggest that it may be useful for the treatment of opioid and cocaine addiction. The neurochemical mechanism(s) underlying ibogaine effects remain unclear. In the present study we investigated the
S D Glick et al.
Annals of the New York Academy of Sciences, 909, 88-103 (2000-07-27)
Ibogaine, one of several alkaloids found in the root bark of the African shrub Tabernanthe iboga, has been claimed to be effective in treating multiple forms of drug abuse. Problems associated with side effects of ibogaine have spawned a search
K K Szumlinski et al.
Pharmacology, biochemistry, and behavior, 63(3), 457-464 (1999-07-27)
Pretreatment (19 h) with the putative antiaddictive agent, ibogaine, has been shown previously to potentiate cocaine-induced locomotion in rats. The present study demonstrates that the magnitude of this effect of ibogaine is dependent on the previous cocaine history of the
B J Vilner et al.
The Journal of pharmacology and experimental therapeutics, 292(3), 900-911 (2000-02-25)
Human SK-N-SH neuroblastoma cells expressed sigma-1 and sigma-2 receptors with similar pharmacological profiles to those of rodent-derived tissues, although sigma-2 receptors exhibited some affinity differences that might suggest heterogeneity or species differences. Structurally diverse sigma ligands produced two types of
G B Wells et al.
Brain research bulletin, 48(6), 641-647 (1999-07-01)
Ibogaine has been shown to affect biogenic amine levels in selected brain regions. Because of the involvement of these neurotransmitters in drug addiction, the effects of ibogaine on biogenic amine transport may contribute to the potential anti-addictive properties of ibogaine
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