This product has not been tested for solubility in DMSO. However, other sources suggest that this compound can be solubilized in DMSO at approximately 10 mg/mL. This information has not been validated.
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I1656
Idarubicin -hydrochlorid
Topoisomerase II inhibitor, solid
Synonym(e):
4-Demethoxydaunorubicin -hydrochlorid
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| Ihnen/SKU | Verfügbarkeit | Preis |
|---|---|---|
10 mg | Warenkorb auf Verfügbarkeit prüfen | € 225,00 |
Über diesen Artikel
Empirische Formel (Hill-System):
C26H27NO9 · HCl
CAS-Nummer:
Molekulargewicht:
533.95
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
260-990-7
MDL number:
Form:
solid
Technischer Dienst
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Unterstützung erhaltenProduktname
Idarubicin -hydrochlorid, solid
form
solid
Quality Segment
originator
Johnson & Johnson
shipped in
wet ice
storage temp.
2-8°C
SMILES string
[H][C@@]1(C[C@@](O)(Cc2c(O)c3C(=O)c4ccccc4C(=O)c3c(O)c12)C(C)=O)O[C@H]5C[C@H](N)[C@H](O)[C@H](C)O5
InChI
1S/C26H27NO9/c1-10-21(29)15(27)7-17(35-10)36-16-9-26(34,11(2)28)8-14-18(16)25(33)20-19(24(14)32)22(30)12-5-3-4-6-13(12)23(20)31/h3-6,10,15-17,21,29,32-34H,7-9,27H2,1-2H3/t10-,15-,16-,17-,21+,26-/m0/s1
InChI key
XDXDZDZNSLXDNA-TZNDIEGXSA-N
Gene Information
human ... TOP2A(7153)
Application
Idarubicin is an anthracycline antibiotic that is an anti-leukemia agent with higher DNA binding capacity and greater cytotoxicity than daunorubicin.
Biochem/physiol Actions
Topoisomerase II inhibitor
Features and Benefits
This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
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Dieser Artikel | |||
|---|---|---|---|
| form solid | form - | form solid | form solid |
| Quality Level 200 | Quality Level - | Quality Level 200 | Quality Level 100 |
| storage temp. 2-8°C | storage temp. −20°C | storage temp. 2-8°C | storage temp. 2-8°C |
| originator Johnson & Johnson | originator - | originator - | originator - |
| shipped in wet ice | shipped in - | shipped in - | shipped in - |
| Gene Information human ... TOP2A(7153) | Gene Information human ... TOP2A(7153) | Gene Information - | Gene Information - |
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signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 2 Oral - Carc. 2 - Repr. 1B
Lagerklasse
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
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Is this soluble in DMSO, if yes then what conc.?
1 answer-
Helpful?
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What is the Department of Transportation shipping information for this product?
1 answer-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
Helpful?
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What is the mode of action for idarubicin?
1 answer-
Idarubicin is an intercalating analog of daunorubicin that interferes with nucleic acid synthesis. It is an anti-tumor antibiotic used in the treatment of leukemia.
Helpful?
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How is idarubicin used therapeutically?
1 answer-
Idarubicin is an antineoplastic drug used to treat AML (Acute Myeloid Leukemia). In addition this compound has also been used in the treatment of breast cancer, non-Hodgkin's lymphoma, and both acute nonlymphocytic and chronic myelogenous leukemias.
Helpful?
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What can be used to make a solution of Idarubicin hydrochloride, Product I1656?
1 answer-
We test the solubility of idarubicin hydrochloride at 20 mg/ml of methanol. Idarubicin hydrochloride is also slightly soluble in water (10 mg/ml water with slight heat) and slightly soluble in ethanol.
Helpful?
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