H6891

7β-Hydroxycholesterol

≥95%

• Synonym(e): 5-Cholestene-3β,7β-diol
• Empirische Formel (Hill-System): C₂₇H₄₆O₂
• CAS-Nummer: 566-27-8
• Molekulargewicht: 402.65
• NACRES: NA.77
• PubChem Substance ID: 24895774
• UNSPSC Code: 12352211
• MDL number: MFCD00058406

Eigenschaften

• Quality Segment: 200
• assay: ≥95%
• form: powder
• functional group: hydroxyl
• shipped in: ambient
• storage temp.: room temp
• SMILES string: [H][C@@]12[C@]([C@](CC[C@H](O)C3)(C)C3=C[C@@H]2O)([H])CC[C@@]4(C)[C@@]1([H])CC[C@]4([H])[C@]([H])(C)CCCC(C)C
• InChI: 1S/C27H46O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h16-18,20-25,28-29H,6-15H2,1-5H3
• InChI key: OYXZMSRRJOYLLO-UHFFFAOYSA-N

Beschreibung

Application

7β-hydroxycholesterol was used to study oxysterol-induced apoptosis in human endothelial cells.

Biochem/physiol Actions

7β-Hydroxycholesterol is an oxysterol, the enzymatic or non-enzymatic product of cholesterol oxidation. Oxysterols are cytotoxic and induce death in monocytes, smooth muscle cells and endothelial cells. The mechanism of apoptosis induced by oxysterols may involve caspases or DNA fragmentation. Increased levels of 7β-Hydroxycholesterol correlates with increased risk of cardiovascular diseases including atherosclerosis.

Preparation Note

7β-Hydroxycholesterol yields clear, colorless to faint yellow solution in ethanol, with or without heating.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable