GW22689B

Anti-MMP12 antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

• UNSPSC-Code: 12352203
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: chicken
• Konjugat: unconjugated
• Antikörperform: affinity isolated antibody
• Antikörper-Produkttyp: primary antibodies
• Klon: polyclonal
• Form: buffered aqueous solution
• Speziesreaktivität: human
• Methode(n): western blot: suitable
• NCBI-Hinterlegungsnummer: NP_002417.1
• UniProt-Hinterlegungsnummer: P39900
• Versandbedingung: wet ice
• Lagertemp.: −20°C
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... MMP12(4321)

Beschreibung

Allgemeine Beschreibung

MMP12 (matrix metalloproteinase 12) is a member of the MMP protein family and is localized to human chromosome 11q22.2-22.3. It is made of nine introns and ten exons, and spans 13kb. It is expressed in a very narrow range of human tissues, and assay of multiple normal human tissues showed its mRNA expression only in placenta. It is found to be expressed in alveolar macrophages of cigarette smokers. It is also called macrophage metalloelastase, and is produced in an inactive form of 54kDa. It is cleaved into an active form of 45kDa, which if further cleaved into 22kDa form. Predominantly, it acts on elastin, and can also degrade fibronectin, laminin, vitronectin etc.

Immunogen

Immunogen Sequence: GI # 4505207, sequence 107-470

Recombinant matrix metalloproteinase 12 preproprotein

Anwendung

Anti-MMP12 antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Biochem./physiol. Wirkung

Matrix metalloproteinase-12 (MMP-12) may act as a specific marker of Stanford-A acute aortic dissection (AAD). The gene is expressed in the primary tumor and acts as a molecular marker that may be useful for predicting extracapsular spread (ECS) in head and neck squamous cell carcinomas (HNSCC) patients with metastatic nodal disease. It may be associated with asthma through inappropriate attraction of leukocytes to the inflamed tissue. It may also serve as a potential diagnostic tool and a therapeutic target in vascular injury and repair.

Physikalische Form

Solution in phosphate buffered saline containing 0.02% sodium azide.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)