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G9502

Guanylyl(3′→5′)uridine ammonium salt

Name: Guanylyl(3′→5′)uridine ammonium salt
Brand: SIGMA

Synonym(e):

GpU

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About This Item

Lineare Formel:

C₁₉H₂₄N₇O₁₃P · NH₃

CAS-Nummer:

41547-83-5

Molekulargewicht:

606.44

MDL-Nummer:

MFCD00058648

UNSPSC-Code:

41106305

PubChem Substanz-ID:

24895373

Form

solid

Lagertemp.

−20°C

SMILES String

N.NC1=NC(=O)c2ncn(C3OC(CO)C(OP(O)(=O)OCC4OC(C(O)C4O)N5C=CC(=O)NC5=O)C3O)c2N1

InChI

1S/C19H24N7O13P.H3N/c20-18-23-14-9(15(32)24-18)21-5-26(14)17-12(31)13(6(3-27)37-17)39-40(34,35)36-4-7-10(29)11(30)16(38-7)25-2-1-8(28)22-19(25)33;/h1-2,5-7,10-13,16-17,27,29-31H,3-4H2,(H,34,35)(H,22,28,33)(H3,20,23,24,32);1H3

InChIKey

BBBUJXLTQPKTLN-UHFFFAOYSA-N

Lagerklassenschlüssel

13 - Non Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

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6S RNA Mimics B-Form DNA to Regulate Escherichia coli RNA Polymerase.

James Chen et al.

Molecular cell, 68(2), 388-397 (2017-10-11)

Noncoding RNAs (ncRNAs) regulate gene expression in all organisms. Bacterial 6S RNAs globally regulate transcription by binding RNA polymerase (RNAP) holoenzyme and competing with promoter DNA. Escherichia coli (Eco) 6S RNA interacts specifically with the housekeeping σ

Structures of an RNA polymerase promoter melting intermediate elucidate DNA unwinding.

Hande Boyaci et al.

Nature, 565(7739), 382-385 (2019-01-11)

A key regulated step of transcription is promoter melting by RNA polymerase (RNAP) to form the open promoter complex1-3. To generate the open complex, the conserved catalytic core of the RNAP combines with initiation factors to locate promoter DNA, unwind

Structural basis for acceptor RNA substrate selectivity of the 3' terminal uridylyl transferase Tailor.

Alena Kroupova et al.

Nucleic acids research, 47(2), 1030-1042 (2018-11-22)

Non-templated 3'-uridylation of RNAs has emerged as an important mechanism for regulating the processing, stability and biological function of eukaryotic transcripts. In Drosophila, oligouridine tailing by the terminal uridylyl transferase (TUTase) Tailor of numerous RNAs induces their degradation by the

Mycobacterial RNA polymerase forms unstable open promoter complexes that are stabilized by CarD.

Elizabeth Davis et al.

Nucleic acids research, 43(1), 433-445 (2014-12-17)

Escherichia coli has served as the archetypal organism on which the overwhelming majority of biochemical characterizations of bacterial RNA polymerase (RNAP) have been focused; the properties of E. coli RNAP have been accepted as generally representative for all bacterial RNAPs.

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