F9553

FTI-276 trifluoroacetate salt

≥95% (HPLC)

• Synonym(e): N-[4-[2-(R)-Amino-3-mercaptopropyl]amino-2-phenylbenzoyl]methionine trifluoroacetate salt
• Empirische Formel (Hill-System): C₂₁H₂₇N₃O₃S₂ ·C₂HF₃O₂
• CAS-Nummer: 170006-72-1
• Molekulargewicht: 547.61
• NACRES: NA.77
• PubChem Substance ID: 329799788
• UNSPSC Code: 12352200
• MDL number: MFCD06409253

Eigenschaften

• Quality Segment: 100
• assay: ≥95% (HPLC)
• form: film
• storage condition: desiccated, under inert gas
• color: off-white
• solubility: H₂O: >5 mg/mL
• shipped in: wet ice
• storage temp.: −20°C
• SMILES string: OC(=O)C(F)(F)F.CSCC[C@H](NC(=O)c1ccc(NC[C@@H](N)CS)cc1-c2ccccc2)C(O)=O
• InChI: 1S/C21H27N3O3S2.C2HF3O2/c1-29-10-9-19(21(26)27)24-20(25)17-8-7-16(23-12-15(22)13-28)11-18(17)14-5-3-2-4-6-14;3-2(4,5)1(6)7/h2-8,11,15,19,23,28H,9-10,12-13,22H2,1H3,(H,24,25)(H,26,27);(H,6,7)/t15-,19+;/m1./s1
• InChI key: IAVHISGQCODLHL-WSCVZUBPSA-N

Beschreibung

Biochem/physiol Actions

FTI-276 is a highly potent RasCAAX peptidomimetic.

FTI-276 is a highly potent RasCAAX peptidomimetic. FTI-276 antagonizes both H and K-Ras oncogenic signaling. It is an inhibitor of farnesyltransferase (Ftase) in vitro with an IC₅₀ of 500 pM and is an anti-cancer agent.

Sicherheitshinweise

• pictograms: GHS07
• signalword: Warning
• hcodes: H315,H319,H335
• pcodes: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves