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Merck

F7307

Fotemustine

≥98% (HPLC)

Synonym(e):

(+-)-Diethyl (1-(3-(2-chloroethyl)-3-nitrosoureido)ethyl)phosphonate, Muphoran, Mustophorane, P-[1-[[[(2-Chloroethyl)nitrosoamino]carbonyl]amino]ethyl]-phosphonic acid diethyl ester, S 10036

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Empirische Formel (Hill-System):
C9H19ClN3O5P
CAS-Nummer:
92118-27-9
Molekulargewicht:
315.69
UNSPSC Code:
12352200
PubChem Substance ID:
329799764
MDL number:
MFCD00866278
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
protect from light

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assay

≥98% (HPLC)

form

powder

storage condition

protect from light

color

light yellow

solubility

H2O: ≥1 mg/mL

originator

Servier

storage temp.

2-8°C

SMILES string

CCOP(=O)(OCC)C(C)NC(=O)N(CCCl)N=O

InChI

1S/C9H19ClN3O5P/c1-4-17-19(16,18-5-2)8(3)11-9(14)13(12-15)7-6-10/h8H,4-7H2,1-3H3,(H,11,14)

InChI key

YAKWPXVTIGTRJH-UHFFFAOYSA-N

Biochem/physiol Actions

Fotemustine is a third generation nitrosourea, chloroethylating agent used in the treatment of glioma and malignant melanoma.

Features and Benefits

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by Servier. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

Health hazard
GHS08

signalword

Warning

hcodes

H351

pcodes

P281

Hazard Classifications

Carc. 2

Lagerklasse

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number
082M4738V
010M4731

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A Silvani et al.
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 32 Suppl 2, S255-S257 (2011-10-12)
Fotemustine (FTMS) is a third-generation nitrosourea, in preclinical studies, FTMS compared favorably with carmustine (BCNU) and lomustine (CCNU) against several human tumor cell lines. In conventional schedule, FTMS is administered at a dose of 100 mg/sqm/week for three consecutive weeks
Mario Balducci et al.
Neuro-oncology, 14(1), 79-86 (2011-10-14)
We explored the feasibility of concurrent palliative chemotherapy and low-dose fractionated radiotherapy (LD-FRT) in glioblastoma multiforme (GBM). Patients with recurrent/progressive GBM at least 3 months after the end of primary radiotherapy received 0.3 Gy twice daily with cisplatin and fotemustine
Aleksandra Ristić-Fira et al.
Radiation protection dosimetry, 143(2-4), 503-507 (2010-12-25)
Response of human HTB140 melanoma cells to proton irradiation in combination with fotemustine (FM) was investigated. Effects of these agents were analysed on cell proliferation and induction of apoptosis. Cells pretreated with 100- or 250-µM of FM were irradiated in
A Farolfi et al.
Journal of chemotherapy (Florence, Italy), 23(5), 300-305 (2011-10-19)
The liver is the primary site of metastases in most uveal melanoma patients. We retrospectively investigated intraarterial chemotherapy (IAC) as treatment for patients with hepatic melanoma metastases.Twenty-three patients (18 with uveal melanoma) received fotemustine (14 patients, 61.9%) or carboplatin (9
Complete response induced by fotemustine given as single agent in a patient with primary central nervous system non-Hodgkin aggressive lymphoma relapsed after high-dose chemotherapy and autologous stem cell support.
Elsa Pennese et al.
Leukemia & lymphoma, 52(11), 2188-2189 (2011-07-02)
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