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Dokumente

F7307

Sigma-Aldrich

Fotemustine

≥98% (HPLC)

Synonym(e):

(+-)-Diethyl (1-(3-(2-chloroethyl)-3-nitrosoureido)ethyl)phosphonate, Muphoran, Mustophorane, P-[1-[[[(2-Chloroethyl)nitrosoamino]carbonyl]amino]ethyl]-phosphonic acid diethyl ester, S 10036

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About This Item

Empirische Formel (Hill-System):
C9H19ClN3O5P
CAS-Nummer:
92118-27-9
Molekulargewicht:
315.69
MDL-Nummer:
MFCD00866278
UNSPSC-Code:
12352200
PubChem Substanz-ID:
329799764

Assay

≥98% (HPLC)

Form

powder

Lagerbedingungen

protect from light

Farbe

light yellow

Löslichkeit

H2O: ≥1 mg/mL

Ersteller

Servier

Lagertemp.

2-8°C

SMILES String

CCOP(=O)(OCC)C(C)NC(=O)N(CCCl)N=O

InChI

1S/C9H19ClN3O5P/c1-4-17-19(16,18-5-2)8(3)11-9(14)13(12-15)7-6-10/h8H,4-7H2,1-3H3,(H,11,14)

InChIKey

YAKWPXVTIGTRJH-UHFFFAOYSA-N

Biochem./physiol. Wirkung

Fotemustine is a third generation nitrosourea, chloroethylating agent used in the treatment of glioma and malignant melanoma.

Leistungsmerkmale und Vorteile

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by Servier. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Piktogramme

Health hazard
GHS08

Signalwort

Warning

H-Sätze

H351

P-Sätze

P281

Gefahreneinstufungen

Carc. 2

Lagerklassenschlüssel

13 - Non Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

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Xavier Durando et al.
Bulletin du cancer, 100(1), 23-28 (2012-08-15)
Brain metastases affect 37% of patients suffering from metastatic melanoma, and their prognosis remains poor, with an overall survival lower than six months. At the moment, there is no standard therapeutic strategy for management of melanoma brain metastases. In some
M Santoni et al.
Anticancer research, 32(3), 1099-1101 (2012-03-09)
Alkylating agents, such as temozolomide (TMZ) and fotemustine (FTM) are widely used in recurrent glioblastoma (GBM) regimes. Several strategies have been proposed to prevent resistance to these agents, by combining or sequencing them. We report the results of a pilot
Ipilimumab with fotemustine in metastatic melanoma.
Claus Garbe
The Lancet. Oncology, 13(9), 851-852 (2012-08-17)
Anna Maria Di Giacomo et al.
The Lancet. Oncology, 13(9), 879-886 (2012-08-17)
Ipilimumab improves survival of patients with metastatic melanoma, many of whom develop brain metastases. Chemotherapy-induced release of tumour antigens might amplify ipilimumab's antitumour activity. We aimed to investigate the efficacy and safety of ipilimumab plus fotemustine in patients with metastatic
Silvia Mangiacavalli et al.
American journal of hematology, 88(2), 102-106 (2012-12-12)
Since multiple myeloma (MM) is still not-curable, the management of relapse remains challenging. Given the known efficacy of alkylating agents in MM, we conducted a phase I/II study to test a new three drug combination in which Fotemustine (Muphoran), an
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