F6889

Famotidin

histamine receptor antagonist

• Synonym(e): N′-(Aminosulfonyl)-3-{[2-(diaminomethylenamino)-4-thiazolyl]-methylthio}-propanamidin
• Empirische Formel (Hill-System): C₈H₁₅N₇O₂S₃
• CAS-Nummer: 76824-35-6
• Molekulargewicht: 337.45
• UNSPSC Code: 12352200
• PubChem Substance ID: 24278442
• NACRES: NA.77
• MDL number: MFCD00079297

Eigenschaften

• Produktname: Famotidin,
• Quality Segment: 100
• originator: Johnson & Johnson
• SMILES string: N\C(N)=N\c1nc(CSCCC(=N)NS(N)(=O)=O)cs1
• InChI: 1S/C8H15N7O2S3/c9-6(15-20(12,16)17)1-2-18-3-5-4-19-8(13-5)14-7(10)11/h4H,1-3H2,(H2,9,15)(H2,12,16,17)(H4,10,11,13,14)
• InChI key: XUFQPHANEAPEMJ-UHFFFAOYSA-N
• Gene Information: human ... HRH2(3274)

Beschreibung

Application

Famotidine has been used to test its effect on the human ether-a-go-go-related gene (hERG) binding transfected in HEK293 membrane. It has also been used in polycaprolactone based drug delivery studies.

Biochem/physiol Actions

H₂ Histamin-Rezeptorantagonist; Antiulcusmittel

Famotidine is not effective on muscarinic and nicotinic receptors. It competitively inhibits the secretion of gastric acid and elicits mucosal injury protection.

Features and Benefits

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)