E7265

Big Endothelin 39 rat

≥97% (HPLC)

• Empirische Formel (Hill-System): C₁₉₂H₂₉₂N₅₀O₅₈S₅
• CAS-Nummer: 135842-15-8
• Molekulargewicht: 4389.00
• UNSPSC Code: 12352202
• NACRES: NA.32
• MDL number: MFCD00151519
• Assay: ≥97% (HPLC)

Eigenschaften

• Quality Segment: 200
• assay: ≥97% (HPLC)
• UniProt accession no.: P22388
• storage temp.: −20°C
• Gene Information: rat ... Edn1(24323)

Beschreibung

General description

Big endothelin-1 is a 39 amino acid peptide, which is synthesized and secreted by vascular smooth muscle and endothelium cells. It is produced as an inactive enzyme, and is cleaved and activated by serine and aspartic proteases and metalloproteinases. Activated form is called ET-1, which is a potent vasoconstrictor. ET-1 is also produced by the action of endothelin converting enzyme (ECE) on big-ET-1. In guinea pigs, big-ET-1 causes the release of prostanoids and thromboxanes.

Application

Big Endothelin 39 rat has been used for charting of a standard curve in the study of the role of ET-1 in ventricular dilatation.

Biochem/physiol Actions

Precursor of Endothelin-1; vasoconstrictor activity appears to be due to its conversion to endothelin 1 by endothelin converting enzyme in the tissue.

Sicherheitshinweise

• pictograms: GHS06
• signalword: Danger
• hcodes: H300 + H330
• pcodes: P260 - P264 - P271 - P284 - P304 + P340 + P310 - P403 + P233
• Hazard Classifications: Acute Tox. 1 Inhalation - Acute Tox. 1 Oral
• Lagerklasse: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)