Direkt zum Inhalt
Merck

E6886

Sigma-Aldrich

5-Ethyluracil

Synonym(e):

2,4-Dihydroxy-5-ethylpyrimidine, Homothymine

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About This Item

Empirische Formel (Hill-System):
C6H8N2O2
CAS-Nummer:
Molekulargewicht:
140.14
MDL-Nummer:
UNSPSC-Code:
41106305
PubChem Substanz-ID:

mp (Schmelzpunkt)

>300 °C (lit.)

SMILES String

CCC1=CNC(=O)NC1=O

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Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Gloves


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V Thielking et al.
Biological chemistry, 378(5), 407-415 (1997-05-01)
Steady-state kinetics of the N6-adenine Dam methyltransferase have been measured using as substrates non-self-complementary tetradecanucleotide duplexes that contain the GATC target sequence. Modifications in the GATC target sequence of one or both of the strands included substitution of guanine by
T Hayakawa et al.
Nucleic acids research, 16(11), 4761-4776 (1988-06-10)
Decadeoxyribonucleotides containing uracil, 5-bromouracil, 5-cyanouracil and 5-ethyluracil in recognition sequences of restriction endonucleases Bgl II, Sau 3AI, Mbo I were synthesized. Decanucleotides containing 5-bromouracil in place of thymine had essentially the same susceptibility to all the restriction endonucleases. Uracil-containing decanucleotides
Montserrat Terrazas et al.
Molecular diversity, 15(3), 677-686 (2010-11-17)
Oligoribonucleotides carrying 5-ethyluridine units were prepared using solid-phase phosphoramidite chemistry. The introduction of the tert-butyldimethylsilyl group at the 2'-OH position proceeded in good yield and very high 2'-regioselectivity. RNA duplexes carrying 5-ethyluridine either at the sense or the guide strands
J L Fischel et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 1(9), 991-996 (1995-09-01)
Dihydropyrimidine dehydrogenase (DPD) is the rate-limiting enzyme of 5-fluorouracil (FU) catabolism. Ethynyluracil (776C) is a very potent, mechanism-based irreversible DPD inhibitor that improves the antitumor efficacy and the therapeutic index of FU in laboratory animals. We tested the cytotoxic effects
S Marzabal et al.
Nucleic acids research, 23(18), 3648-3655 (1995-09-25)
We have measured steady-state kinetics of the N6-adenine methyltransferase Dam Mtase using as substrates non-selfcomplementary tetradecamer duplexs (d[GCCGGATCTAGACG]-d[CGTCTAGATCC-GGC]) containing the hemimethylated GATC target sequence in one or the other strand and modifications in the GATC target sequence of the complementary

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