E1631

β-Estradiol 17-Valerat

≥98% (HPLC), powder

• Synonym(e): 1,3,5(10)-Estratrien-3,17β-diol 17-pentanoat
• Empirische Formel (Hill-System): C₂₃H₃₂O₃
• CAS-Nummer: 979-32-8
• Molekulargewicht: 356.50
• NACRES: NA.77
• PubChem Substance ID: 24894423
• UNSPSC Code: 41116107
• EC Number: 213-559-2
• MDL number: MFCD00056541
• Beilstein/REAXYS Number: 2480357
• Assay: ≥98%
• Form: powder
• Quality level: 100

Eigenschaften

• Produktname: β-Estradiol 17-Valerat, ≥98%
• InChI key: RSEPBGGWRJCQGY-UHFFFAOYSA-N
• InChI: 1S/C23H32O3/c1-3-4-5-22(25)26-21-11-10-20-19-8-6-15-14-16(24)7-9-17(15)18(19)12-13-23(20,21)2/h7,9,14,18-21,24H,3-6,8,10-13H2,1-2H3
• SMILES string: CCCCC(=O)OC1CCC2C3CCc4cc(O)ccc4C3CCC12C
• biological source: synthetic
• assay: ≥98%
• form: powder
• technique(s): ELISA: suitable
• solubility: acetone: 25 mg/mL, hazy, colorless
• shipped in: ambient
• storage temp.: room temp
• Quality Level: 100

Beschreibung

General description

β-Estradiol 17-valerate is a synthetic estrogen.[1]

Application

β-Estradiol 17-valerate has been used:

• in an in-vivo assay, to synchronize the estrus cycle in athymic nude mice, to study the effect of recombinant pigment epithelium-derived factor (rPEDF) on induced ectopic fibroid lesions[2]
• to study the influence of ovarian hormones on type II cGMP-dependent protein kinase (Prkg2) expression in mice[3]
• to induce growth of estrogen-dependent tumor cells in athymic nude mice to establish a breast cancer mouse model[4]

Biochem/physiol Actions

Estradiol valerate is observed to be useful for treating menopausal climacteric symptoms.[5] β-Estradiol 17-valerate is used as a source of 17β-estradiol (E2) in in vitro fertilization, hormone replacement therapy, contraceptive drugs, to study reproductive disorders in animal models.[1] It serves as growth promoter in animal farming. β-Estradiol 17-valerate is also used to culture single-sex population among fish. Studies in rats show that β-Estradiol 17-valerate has negative effects on the estrus cycle pattern.[1]

Sicherheitshinweise

• pictograms: GHS08,GHS09
• signalword: Warning
• hcodes: H351,H361fd,H362,H410
• pcodes: P201 - P202 - P260 - P263 - P273 - P308 + P313
• Hazard Classifications: Aquatic Chronic 1 - Carc. 2 - Lact. - Repr. 2
• Lagerklasse: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3
• ppe: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges