E0907

Anti-phospho-Epidermal Growth Factor Receptor (pTyr⁸⁴⁵) antibody produced in rabbit

affinity isolated antibody, lyophilized powder

• Synonym(e): Anti-phospho-EGFR (pTyr⁸⁴⁵)
• UNSPSC Code: 51111800
• MDL number: MFCD03845329
• Conjugate: unconjugated
• Clone: polyclonal
• Application: flow cytometry; immunohistochemistry; western blot
• Species reactivity: human
• Citations: 3
• Technique(s): flow cytometry: 5 μg/mL; immunohistochemistry: 15 μg/mL; western blot: 0.5 μg/mL
• Uniprot accession no.: P00533

Eigenschaften

• Produktname: Anti-phospho-Epidermal Growth Factor Receptor (pTyr⁸⁴⁵) antibody produced in rabbit, affinity isolated antibody, lyophilized powder
• biological source: rabbit
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: lyophilized powder
• species reactivity: human
• technique(s): flow cytometry: 5 μg/mL; immunohistochemistry: 15 μg/mL; western blot: 0.5 μg/mL
• UniProt accession no.: P00533
• storage temp.: −20°C
• Quality Level: 100
• Gene Information: human ... EGFR(1956)

Beschreibung

Biochem/physiol Actions

EGFR is a transmembrane glycoprotein that binds to the EGF family. It is a pivotal regulator of cell proliferation, growth, differentiation and DNA repair after radiation-induced damage. Mutations in the gene encoding EGFR are associated with a number of malignancies including lung cancer and colorectal cancer. Phosphorylation of Tyr845 is associated with EGFR mutation and serves as a surrogate marker.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Immunogen

purified, synthetic phosphopeptide corresponding to residues surrounding tyrosine 845 of human epidermal growth factor receptor.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.

Sicherheitshinweise

• Lagerklasse: 13 - Non Combustible Solids
• wgk: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)