E0162
Carboxylesterase 1 isoform c human
recombinant, expressed in baculovirus infected BTI insect cells
Synonym(e):
Carboxylesterase 1 human, carboxylesterase, esterase
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Unterstützung erhaltenrecombinant
expressed in baculovirus infected BTI insect cells
form
liquid
concentration
≥0.3 mg/mL
shipped in
dry ice
storage temp.
−70°C
Quality Level
1 of 4
Dieser Artikel | |||
|---|---|---|---|
| recombinant expressed in baculovirus infected BTI insect cells | recombinant expressed in baculovirus infected BTI insect cells | recombinant expressed in baculovirus infected BTI insect cells | recombinant - |
| form liquid | form liquid | form liquid | form - |
| concentration ≥0.3 mg/mL | concentration 5 mg/mL | concentration - | concentration - |
| shipped in dry ice | shipped in dry ice | shipped in dry ice | shipped in wet ice |
| storage temp. −70°C | storage temp. −70°C | storage temp. −70°C | storage temp. - |
| Quality Level 200 | Quality Level 200 | Quality Level 200 | Quality Level 100 |
General description
Carboxylesterase 1 (CE1) is a member of a large multigene[1] carboxylesterase α,β-hydrolase family.[2] It is majorly expressed in the liver.[2] CE1 comprises an αβ domain, a central catalytic domain and a regulatory domain.[2]
This product is offered in a volume of 0.5 mL.
Application
Carboxylesterase 1 isoform c human has been used as a reference standard in carboxylesterase activity from the mussel for comparison of substrate specificity and inhibition studies.[3] It has also been used as a commercial recombinant protein for the methodological validation of environmental chemical-based inhibition studies.[4]
Biochem/physiol Actions
Carboxylesterase enzymes are responsible for the hydrolysis of ester- and amide-bond-containing drugs such as cocaine and heroin.[2] They also hydrolyze long-chain fatty acid esters and thioesters. Carboxylesterase 1 (CE1) catalyzes the formation of cholesteryl esters from cholesterol and fatty acids. Through a transesterification reaction, CE1 also mediates the generation of fatty acid ethyl esters (FAEEs).[2] It also hydrolyzes aromatic and aliphatic esters[5] with preference to small alcohol groups and bulky acyl groups.[6] CE1 metabolizes drug esters and amides carbamates.[5] It participates in the detoxification of environmental toxicants and carcinogens and is useful in pharmacokinetic studies for evaluating pro-drugs.[7]
Other Notes
One unit will hydrolyze one nanomole of 4-nitrophenyl acetate per minute at pH 7.4 at 37 °C.
signalword
Danger
hcodes
Hazard Classifications
Resp. Sens. 1
Lagerklasse
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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Masakiyo Hosokawa
Molecules (Basel, Switzerland), 13(2), 412-431 (2008-02-29)
Mammalian carboxylesterases (CESs) comprise a multigene family whose gene products play important roles in biotransformation of ester- or amide-type prodrugs. They are members of an alpha,beta-hydrolase-fold family and are found in various mammals. It has been suggested that CESs can
Carboxylesterases: sources, characterization and broader applications
Sood S, et al.
Insight (American Society of Ophthalmic Registered Nurses), 1, 1-11 (2016)
Plasmatic B-esterases as potential biomarkers of exposure to marine plastics in loggerhead turtles.
Sole, et al.
Environmental Research, 213, 113639-113639 (2022)
Jihong Lian et al.
Protein & cell, 9(2), 178-195 (2017-07-06)
Mammalian carboxylesterases hydrolyze a wide range of xenobiotic and endogenous compounds, including lipid esters. Physiological functions of carboxylesterases in lipid metabolism and energy homeostasis in vivo have been demonstrated by genetic manipulations and chemical inhibition in mice, and in vitro
Montserrat Solé et al.
Environmental toxicology and pharmacology, 82, 103561-103561 (2020-12-12)
Carboxylesterases (CEs) are key enzymes which catalyse the hydrolysis reactions of multiple xenobiotics and endogenous ester moieties. Given their growing interest in the context of marine pollution and biomonitoring, this study focused on the in vitro sensitivity of marine invertebrate
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