D8942
Dichlorophenyl-ABA
≥98% (HPLC), solid
Synonym(e):
2-[(3,5-Dichlorophenyl)amino]benzoic acid
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Empirische Formel (Hill-System):
C13H9Cl2NO2
CAS-Nummer:
Molekulargewicht:
282.12
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
Technischer Dienst
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Unterstützung erhaltenassay
≥98% (HPLC)
form
solid
color
white
solubility
DMSO: ~18 mg/mL at ~60 °C
storage temp.
2-8°C
SMILES string
OC(=O)c1ccccc1Nc2cc(Cl)cc(Cl)c2
InChI
1S/C13H9Cl2NO2/c14-8-5-9(15)7-10(6-8)16-12-4-2-1-3-11(12)13(17)18/h1-7,16H,(H,17,18)
InChI key
FNGSQOJHNAYHAT-UHFFFAOYSA-N
Gene Information
human ... TTR(7276)
Biochem/physiol Actions
Inhibitor of transthyretin amyloid fibril formation in vitro.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Lagerklasse
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Natàlia Reixach et al.
Proceedings of the National Academy of Sciences of the United States of America, 101(9), 2817-2822 (2004-02-26)
The transthyretin (TTR) amyloidoses are human diseases in which the misfolded TTR protein aggregates in tissues with subsequent visceral, peripheral, and autonomic nerve dysfunction. Recent reports have stressed the importance of oligomeric intermediates as major cytotoxic species in various forms
Per Hammarström et al.
Science (New York, N.Y.), 299(5607), 713-716 (2003-02-01)
Genetic evidence suggests that inhibition of amyloid fibril formation by small molecules should be effective against amyloid diseases. Known amyloid inhibitors appear to function by shifting the aggregation equilibrium away from the amyloid state. Here, we describe a series of
Ellen Y Cotrina et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 26(72), 17462-17469 (2020-08-08)
The protein transthyretin (TTR) modulates amyloid-β (Aβ) peptides deposition and processing and this physiological effect is further enhanced by treatment with iododiflunisal (IDIF), a small-molecule compound (SMC) with TTR tetramer stabilization properties, which behaves as chaperone of the complex. This