D7000

11-Deoxycorticosteronacetat

• Synonym(e): 21-Acetoxy-4-pregnen-3,20-dion, 21-Acetoxy-progesteron, 21-Hydroxy-4-pregnen-3,20-dion-21-acetat, 21-Hydroxy-progesteron-21-acetat, 4-Pregnen-21-ol-3,20-dion-21-acetat, Cortexonacetat, DOC-acetat, Desoxycorticosteronacetat
• Empirische Formel (Hill-System): C₂₃H₃₂O₄
• CAS-Nummer: 56-47-3
• Molekulargewicht: 372.50
• Beilstein: 2570798
• EG-Nummer: 200-275-9
• MDL-Nummer: MFCD00003660
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24894065
• NACRES: NA.77

Eigenschaften

• Biologische Quelle: synthetic (organic)
• Sterilität: non-sterile
• Assay: ≥98% (HPLC)
• Form: powder
• Löslichkeit: H₂O: insoluble; acetone: soluble (1 in 30); alcohol: soluble (1 in 50); chloroform: freely soluble; dioxane: slightly soluble; vegetable oils: slightly soluble
• Versandbedingung: ambient
• Lagertemp.: room temp
• SMILES String: [H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])CC[C@]4(C)[C@]([H])(CC[C@@]24[H])C(=O)COC(C)=O
• InChI: 1S/C23H32O4/c1-14(24)27-13-21(26)20-7-6-18-17-5-4-15-12-16(25)8-10-22(15,2)19(17)9-11-23(18,20)3/h12,17-20H,4-11,13H2,1-3H3/t17-,18-,19-,20+,22-,23-/m0/s1
• InChIKey: VPGRYOFKCNULNK-ACXQXYJUSA-N
• Angaben zum Gen: human ... NR3C2(4306)

Beschreibung

Allgemeine Beschreibung

Deoxycorticosterone acetate is an endogenous neurosteroid found in brain and peripheral circulation, which is produced by progesterone. It is both a mineralocorticoid and a glucocorticoid. It is used to treat adrenocortical insufficiency or Addison′s disease. Deoxycorticosterone acetate improves insulin sensitivity. It acts as a precursor to glucocorticoid corticosterone and the GABAergic neuroactive steroid (3α,5α)-3,21-dihydroxypregnan-20-one.

Anwendung

Deoxycorticosterone acetate has been used to induce hypertensive pregnancy. It has also been used to investigate the effect of low epicatechin dosing on the cardiovascular function of deoxycorticosterone acetate (DOCA)-salt hypertensive rats.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)