D5321

D36 hydrate

≥98% (HPLC)

• Synonym(e): 5-(2-methoxyphenyl)-1-(2-methylpropyl)-1H-Indole-3-acetamide Hydrate
• Empirische Formel (Hill-System): C₂₁H₂₄N₂O₂ · xH₂O
• CAS-Nummer: 1228184-64-2
• Molekulargewicht: 336.43 (anhydrous basis)
• MDL-Nummer: MFCD16875421
• UNSPSC-Code: 51111800
• PubChem Substanz-ID: 329798803

Eigenschaften

• Assay: ≥98% (HPLC)
• Form: powder
• Lagerbedingungen: desiccated
• Farbe: white to off-white
• Löslichkeit: DMSO: >10 mg/mL
• Ersteller: GlaxoSmithKline
• Lagertemp.: 2-8°C
• SMILES String: O.COc1ccccc1-c2ccc3n(CC(C)C)cc(CC(N)=O)c3c2
• InChI: 1S/C21H24N2O2.H2O/c1-14(2)12-23-13-16(11-21(22)24)18-10-15(8-9-19(18)23)17-6-4-5-7-20(17)25-3;/h4-10,13-14H,11-12H2,1-3H3,(H2,22,24);1H2
• InChIKey: ZERKAKHVUQMJPW-UHFFFAOYSA-N

Beschreibung

Biochem./physiol. Wirkung

D36 is an androgen receptor (AR) allosteric antagonist with inverse agonist properties. D36 inhibits both wild-type and agonist-induced AR activity and antagonized AR in a hormone-refractory model.

Leistungsmerkmale und Vorteile

This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable