D4434

Dichloromethylenediphosphonic acid disodium salt

Name: Dichloromethylenediphosphonic acid disodium salt
Brand: SIGMA
Price: 307 EUR

osteoclastic activity inhibitor, powder

Synonym(e):

Cl₂MDP, Clodronate disodium, Clodronic acid disodium salt, DMDP

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Über diesen Artikel

Lineare Formel:

CH₂O₆Cl₂Na₂P₂

CAS-Nummer:

22560-50-5

Molekulargewicht:

288.86

NACRES:

NA.77

PubChem Substance ID:

24278371

UNSPSC Code:

12352106

EC Number:

245-078-9

MDL number:

MFCD01632786

Form:

powder

Quality level:

300

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Unterstützung erhalten

Produktname

Dichloromethylenediphosphonic acid disodium salt,

form

powder

InChI key

HJKBJIYDJLVSAO-UHFFFAOYSA-L

InChI

1S/CH4Cl2O6P2.2Na/c2-1(3,10(4,5)6)11(7,8)9;;/h(H2,4,5,6)(H2,7,8,9);;/q;2*+1/p-2

SMILES string

[Na+].[Na+].OP([O-])(=O)C(Cl)(Cl)P(O)([O-])=O

solubility

water: 49.00-51.00 mg/mL, clear, colorless

storage temp.

room temp

Quality Level

300

Gene Information

rat ... Man2a1(25478), Si(497756)

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Dieser Artikel	D6899	D3506	233183
Sigma-Aldrich D4434 Dichloromethylenediphosphonic acid disodium salt	Sigma-Aldrich D6899 Diclofenac sodium salt	Sigma-Aldrich D3506 Sodium diethyldithiocarbamate trihydrate	Sigma-Aldrich 233183 Clodronate, Disodium Salt
form powder	form powder	form powder or crystals	form solid
Quality Level 300	Quality Level 100	Quality Level 200	Quality Level 100
storage temp. room temp	storage temp. room temp	storage temp. room temp	storage temp. 2-8°C
solubility water: 49.00-51.00 mg/mL, clear, colorless	solubility methanol: 50 mg/mL, clear, colorless to faint yellow or tan	solubility water: 1 g/10 mL, slightly hazy	solubility water: 1 mg/mL
Gene Information rat ... Man2a1(25478), Si(497756)	Gene Information human ... PTGS1(5742), PTGS2(5743)	Gene Information -	Gene Information -

Biochem/physiol Actions

Analog of pyrophosphate ion that inhibits the osteoclastic activity leading to bone resorption and osteoporosis. The compound is used in cancer research, especially in skeletal metastases and breast carcinoma.[1][2] When entrapped in liposomes, it is used for macrophage-selective depletion (macrophage "suicide" technique), especially in spleen and liver.[3] Found also to inhibit collagenase and matrix metalloproteinase1.[4]

Lagerklasse

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Hepatic crown-like structure: a unique histological feature in non-alcoholic steatohepatitis in mice and humans.

Michiko Itoh et al.

PloS one, 8(12), e82163-e82163 (2013-12-19)

Although macrophages are thought to be crucial for the pathogenesis of chronic inflammatory diseases, how they are involved in disease progression from simple steatosis to non-alcoholic steatohepatitis (NASH) is poorly understood. Here we report the unique histological structure termed "hepatic

Impact of PPAR-α induction on glucose homoeostasis in alcohol-fed mice.

Valérie Lebrun et al.

Clinical science (London, England : 1979), 125(11), 501-511 (2013-06-14)

Alcohol consumption is a major cause of liver disease. It also associates with increased cardiovascular risk and Type 2 diabetes. ALD (alcoholic liver disease) and NAFLD (non-alcoholic fatty liver disease) share pathological features, pathogenic mechanisms and pattern of disease progression.

The liposome-mediated macrophage 'suicide' technique.

N Van Rooijen

Journal of immunological methods, 124(1), 1-6 (1989-11-13)

Macrophages form an important cell population involved in numerous immunological processes. Techniques which eliminate these cells, in order to permit 'in vivo' studies of their function are generally imperfect and for that reason we have developed a method using the

Inhibition of matrix metalloproteinase-1 by dichloromethylene bisphosphonate (clodronate).

O Teronen et al.

Calcified tissue international, 61(1), 59-61 (1997-07-01)

Interstitial collagenase present in human jaw cyst extract and purified human fibroblast-type collagenase (MMP-1) were both efficiently inhibited in vitro by clodronate, an osteoactive, antiresorptive bisphosphonate. The IC50 of clodronate to inhibit MMP-1 is 150 microM. These findings suggest an

Bisphosphonates and breast carcinoma.

A Lipton

Cancer, 80(8 Suppl), 1668-1673 (1997-11-15)

The skeleton is a common site of breast carcinoma metastasis; 75% of patients with breast carcinoma demonstrate bone metastases at autopsy. The lytic destruction of bone in these patients is due to excessive osteoclastic activity. By reducing osteoclastic activity, bisphosphonates

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Dichloromethylenediphosphonic acid disodium salt