This product, in the original unopened container, is quite stable. The product is not assigned an expiration or retest date, but is warrantied for 1 year from the date of shipment. Storage of the powder material refrigerated, at 2-8°C, is not expected to be detrimental. However, allow the product to reach ambient temperature prior to opening to avoid moisture uptake.
Please see the link below to review the current product dating policy:
https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/356/113/product-dating-information-06-25-ms.pdf
Fortfahren mit
D2915
Dexamethason – wasserlöslich
BioReagent, suitable for cell culture
Synonym(e):
Dexamethason – Cyclodextrinkomplex
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| Ihnen/SKU | Verfügbarkeit | Preis |
|---|---|---|
100 mg | Warenkorb auf Verfügbarkeit prüfen | € 342,00 |
Über diesen Artikel
CAS-Nummer:
MDL number:
UNSPSC Code:
12352209
PubChem Substance ID:
EC Number:
200-003-9
NACRES:
NA.77
Biological source:
synthetic (organic)
Form:
solid
Technischer Dienst
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Unterstützung erhaltenbiological source
synthetic (organic)
Quality Segment
product line
BioReagent
form
solid
technique(s)
cell culture | mammalian: suitable
solubility
H2O: 25 mg/mL, clear to slightly hazy
shipped in
ambient
storage temp.
room temp
SMILES string
C[C@@H]1CC2C3CCC4=CC(=O)C=C[C@]4(C)C3[C@@H](O)C[C@]2(C)[C@H]1C(=O)CO.OC[C@H]5O[C@@H]6O[C@H]7[C@H](O)[C@@H](O)[C@H](O[C@@H]7CO)O[C@H]8[C@H](O)[C@@H](O)[C@H](O[C@@H]8CO)O[C@H]9[C@H](O)[C@@H](O)[C@H](O[C@@H]9CO)O[C@H]%10[C@H](O)[C@@H](O)[C@H](O[C@@H]%10CO)O[C@H]%11[C@H](O)[C@@H](O)[C@H](O[C@@H]%11CO)O[C@H]%12[C@H](O)[C@@H](O)[C@H](O[C@@H]%12CO)O[C@H]5[C@H](O)[C@H]6O
InChI
1S/C42H70O35.C22H30O4/c43-1-8-29-15(50)22(57)36(64-8)72-30-9(2-44)66-38(24(59)17(30)52)74-32-11(4-46)68-40(26(61)19(32)54)76-34-13(6-48)70-42(28(63)21(34)56)77-35-14(7-49)69-41(27(62)20(35)55)75-33-12(5-47)67-39(25(60)18(33)53)73-31-10(3-45)65-37(71-29)23(58)16(31)51;1-12-8-16-15-5-4-13-9-14(24)6-7-21(13,2)20(15)17(25)10-22(16,3)19(12)18(26)11-23/h8-63H,1-7H2;6-7,9,12,15-17,19-20,23,25H,4-5,8,10-11H2,1-3H3/t8-,9-,10-,11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23-,24-,25-,26-,27-,28-,29-,30-,31-,32-,33-,34-,35-,36-,37-,38-,39-,40-,41-,42-;12-,15+,16?,17+,19-,20-,21+,22+/m11/s1
InChI key
XEJNDGTUKUMQNG-ARJMFYCQSA-N
Application
Dexamethason – wasserlöslich wird verwendet als Bestandteil von:
- osteogenem und adipogenem Medium auf Grundlage von Dulbeccos modifiziertem Eagle-Medium für Kulturen humaner mesenchymaler Stammzellen
- Erythroid-Expansionsmedien für das Wachstum von Leber-, Knochenmark- und Milzgeweben
- Medium 199 (M199) für Hepatozyten-Kulturen
Biochem/physiol Actions
Dexamethason ist ein entzündungshemmendes Glukokortikoid und ein synthetisches Kortikosteroid, das zur Behandlung von Hornhautentzündungen verwendet wird. Es hemmt die IL-1β-abhängige Angiogenese. Dexamethason hat Auswirkungen auf Zellüberleben, zelluläre Signaltransduktion und Genexpressionen. Es begünstigt die Apoptose von Chondrozyten und beeinträchtigt die Knochenbildung. Dexamethason ist ein mögliches Therapeutikum, da es in Zellen des multiplen Myeloms (MM) die Apoptose induziert. Sein Wirkmechanismus geht darauf zurück, dass es die Menge von Glukokortikoid-Rezeptor (GR) α verringert und die Progression von Kolontumoren hemmt.
Packaging
Packungsgröße basiert auf Dexamethason
Other Notes
Enthält ca. 65 mg Dexamethason pro Gramm; Ausgleich Methyl-β-Cyclodextrin.
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Dieser Artikel | |||
|---|---|---|---|
| biological source synthetic (organic) | biological source - | biological source synthetic | biological source synthetic (organic) |
| Quality Level 200 | Quality Level 300 | Quality Level 200 | Quality Level 200 |
| product line BioReagent | product line - | product line BioReagent | product line BioXtra |
| technique(s) cell culture | mammalian: suitable | technique(s) gas chromatography (GC): suitable, liquid chromatography (LC): suitable | technique(s) cell culture | mammalian: suitable, single cell analysis: suitable | technique(s) cell culture | mammalian: suitable |
| form solid | form liquid | form powder | form powder |
| solubility H2O: 25 mg/mL, clear to slightly hazy | solubility - | solubility methanol: 25 mg/mL | solubility ethanol: 1 mL/vial, clear |
signalword
Danger
hcodes
Hazard Classifications
Repr. 1B
Lagerklasse
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.
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Quelle est la stabilité du produit quand il est conservé selon les recommendations du fournisseur? Est-ce qu'un stockage à 4°C au lieu de température ambiante diminue sa durée de vie?
1 answer-
Helpful?
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what is the wavelength of absorbance for detecting dexamethasone cyclodextrin complex in DI water in quantitative analysis?
1 answer-
The absorption wavelength for detecting dexamethasone is approximately 240 nm. However, this product has not been measured for absorption.
Helpful?
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How long is Product D2915 stable in solid form?
1 answer-
For certain products, the certificate of analysis may only display the Release Date, without a specified Retest, Expiration, or Use-by-Date. In such cases, the standard warranty of 1 year from the date of shipment applies. This product should remain stable in solid form for at least 1 year if stored correctly. For additional information on the warranty, refer to the terms and conditions of sale. Product Dating Information.
Helpful?
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D2915 is light sensitive?
1 answer-
This material is considered light sensitive and is packaged in amber glass bottles.
Helpful?
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What is the molecular mass of Dexamethasone-Water Soluble (D2915)?
1 answer-
This product is a multi-component item comprised of dexamethasone and (2-Hydroxypropyl)-?-cyclodextrin. The molecular weight of Dexamethasone is 392.5 g/mol. The molecular weight of the (2-Hydroxypropyl)-?-cyclodextrin is variable, but has an average molecular weight of 1,396 g/mol. There is an excess of cyclodextrin in the mixture to greatly enhance the solubility of the dexamethasone. The product is sold on the basis of the Dexamethasone content. The final product will have 55 - 75 mg of Dexamethasone per gram solid. For example, a 100mg package reporting a 75mg/gram Dexamethasone concentration would be a package of 1.81 grams. This value is reported in the Certiicate of Analysis. Please see the link below to review a sample of a specific Certificate:
https://www.sigmaaldrich.com/US/en/product/sigma/d2915#product-informationHelpful?
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How should stock solutions for item D2915-100MG be stored?
1 answer-
Stock solutions can be stored for up to 2 months at -20°C.
Helpful?
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What is the recommended method for storing prepared solutions of D2915 dexamethasone water-soluble?
1 answer-
The recommended method for storing prepared solutions of D2915 dexamethasone water-soluble is to store the solutions in working aliquots at -20°C.
Helpful?
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Is the 100mg labeled on the bottle of D2915 Dexamethasone for the total powder or the total dexamethasone?
1 answer-
Each vial contains 100 mg of dexamethasone. The mg of dexamethasone per gram is provided on the label, typically around 65 mg/g.
Helpful?
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Is additional solubility data available for product D2915, Dexamethasone-Water Soluble?
1 answer-
The solubility of product D2915, Dexamethasone-Water Soluble, has been tested only in water, with a solubility (turbidity) of clear to slightly hazy at 25 mg/mL in water. Additionally, It is also soluble in ethanol (25 mg/mL), DMSO (25 mg/mL), and DMF (25 mg/mL).
Helpful?
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Once this product has been reconstituted in water, how long can it be stored, and at what temperature?
1 answer-
Stock solutions may be stored in working aliquots at -20ºC. Please see the link below for additional information on the Water Soluble Complexes, including Dexamethasone, Water Soluble:
https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/documents/218/859/e8014inf.pdfHelpful?
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