D2667
2,5-Dihydroxycinnamic acid methyl ester
≥95%, crystalline
Synonym(e):
Erbstatin analog, Methyl 2,5-dihydroxycinnamate
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Empirische Formel (Hill-System):
C10H10O4
CAS-Nummer:
Molekulargewicht:
194.18
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
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Unterstützung erhaltenassay
≥95%
form
crystalline
color
yellow
mp
181-183 °C
solubility
0.1 M NaOH: soluble, H2O: insoluble, methanol: soluble
storage temp.
−20°C
SMILES string
COC(=O)\C=C\c1cc(O)ccc1O
InChI
1S/C10H10O4/c1-14-10(13)5-2-7-6-8(11)3-4-9(7)12/h2-6,11-12H,1H3/b5-2+
InChI key
BQCNSTFWSKOWMA-GORDUTHDSA-N
Biochem/physiol Actions
Inhibitor of EGF receptor-associated tyrosine kinase.
Other Notes
Stable analog of erbstatin.
Disclaimer
Photosensitive.
Lagerklasse
11 - Combustible Solids
wgk
WGK 3
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
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J Sandy et al.
Bone, 23(1), 17-26 (1998-07-14)
This investigation examined which signal pathways are of relevance in growth factor-stimulated bone cell mitogenesis. Platelet-derived growth factor (PDGF) and insulin-like growth factor-II (IGF-II) were potent mitogens for both the MG-63 osteoblast cell line and for primary cultures of human
P S Leventhal et al.
Brain research. Molecular brain research, 43(1-2), 338-340 (1996-12-31)
In the current studies, we investigated the relationship between tyrosine phosphorylation and neurite formation. In SH-SY5Y neuroblastoma cells, the tyrosine kinase inhibitor methyl 2, 5-dihydroxycinnimate blocked neurite formation on laminin. This corresponded with inhibition of paxillin and focal adhesion kinase
O S Ruiz et al.
Regulatory peptides, 77(1-3), 155-161 (1998-11-11)
To examine the role of tyrosine kinase (TK) on basolateral membrane (BLM) transport, we looked for the presence of TK activity in these membranes and showed that the synthetic substrate for TK, poly [Glu80 Na, Tyr20] caused a three-fold increase
R R Hartmann et al.
Melanoma research, 7 Suppl 2, S27-S33 (1997-08-01)
Differentiation therapy is an attractive option for malignant melanoma, as traditional forms of chemotherapy seem to have little effect on this type of tumour. Among the several pathways for the experimental induction of differentiation of melanoma, we have focused on
P Lassota et al.
The Journal of biological chemistry, 271(42), 26418-26423 (1996-10-18)
Topoisomerase II is an essential enzyme for proliferation of eukaryotic cells. It is also a target for many antineoplastic drugs that promote stabilization of covalent complexes between topoisomerase II and DNA. Topoisomerase II and protein kinases both catalyze the transfer
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