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D0929

3,3′-Diheptyl-oxacarbocyanin-iodid

Name: 3,3′-Diheptyl-oxacarbocyanin-iodid
Brand: SIGMA

Synonym(e):

DiOC₇(3)

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About This Item

Empirische Formel (Hill-System):

C₃₁H₄₁IN₂O₂

CAS-Nummer:

53213-83-5

Molekulargewicht:

600.57

MDL-Nummer:

MFCD00274413

UNSPSC-Code:

12171500

PubChem Substanz-ID:

24893311

Fluoreszenz

λ_ex 484 nm; λ_em 504 nm in methanol

SMILES String

[I-].CCCCCCCN1C(\Oc2ccccc12)=C\C=C\c3oc4ccccc4[n+]3CCCCCCC

InChI

1S/C31H41N2O2.HI/c1-3-5-7-9-15-24-32-26-18-11-13-20-28(26)34-30(32)22-17-23-31-33(25-16-10-8-6-4-2)27-19-12-14-21-29(27)35-31;/h11-14,17-23H,3-10,15-16,24-25H2,1-2H3;1H/q+1;/p-1

InChIKey

ANJZLSIIEGUCQL-UHFFFAOYSA-M

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Piktogramme

GHS08,GHS07

Signalwort

Danger

H-Sätze

H315,H319,H335,H360

P-Sätze

P201 - P302 + P352 - P305 + P351 + P338 - P308 + P313

Gefahreneinstufungen

Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2 - STOT SE 3

Zielorgane

Respiratory system

Lagerklassenschlüssel

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type P2 (EN 143) respirator cartridges

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Targeting the tumour vasculature: exploitation of low oxygenation and sensitivity to NOS inhibition by treatment with a hypoxic cytotoxin.

Jennifer H E Baker et al.

PloS one, 8(10), e76832-e76832 (2013-11-10)

Many cancer research efforts focus on exploiting genetic-level features that may be targeted for therapy. Tissue-level features of the tumour microenvironment also represent useful therapeutic targets. Here we investigate the presence of low oxygen tension and sensitivity to NOS inhibition

Pontentiometric cyanine dyes are sensitive probes for mitochondria in intact plant cells : kinetin enhances mitochondrial fluorescence.

Z Liu et al.

Plant physiology, 84(4), 1385-1390 (1987-08-01)

Selected fluorescent dyes were tested for uptake by mitochrondria in intact cells of barley, maize, and onion. The cationic cyanine dye 3,3'-diheptyloxacarbocyanine iodide [DiOC(7)(3)] accumulated in mitochondria within 15 to 30 minutes without appreciable staining of other protoplasmic constituents. The

Use of a carbocyanine dye as a marker of functional vasculature in murine tumours.

M J Trotter et al.

British journal of cancer, 59(5), 706-709 (1989-05-01)

An intravenously administered fluorescent carbocyanine dye, DiOC7(3), has been evaluated for use in conjunction with Hoechst 33342 as a marker of murine tumour vasculature. DiOC7(3) stains cells immediately adjacent to blood vessels and thus, like Hoechst 33342, outlines perfused tumour

Tissue penetration and activity of camptothecins in solid tumor xenografts.

Alastair H Kyle et al.

Molecular cancer therapeutics, 13(11), 2727-2737 (2014-08-22)

The ability of a panel of camptothecin derivatives to access the tumor compartment was evaluated to determine the mechanisms by which the architecture of solid tumors may act to limit their activity. Microregional localization and activity of members of the

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