C5612

Anti-CD30 Ligand antibody produced in goat

affinity isolated antibody, lyophilized powder

• Synonym(e): Anti-CD30L
• MDL-Nummer: MFCD01864203
• UNSPSC-Code: 12352203

Eigenschaften

• Biologische Quelle: goat
• Konjugat: unconjugated
• Antikörperform: affinity isolated antibody
• Antikörper-Produkttyp: primary antibodies
• Klon: polyclonal
• Form: lyophilized powder
• Speziesreaktivität: mouse
• Methode(n): indirect ELISA: 0.5-1.0 μg/mL; western blot: 0.1-0.2 μg/mL
• UniProt-Hinterlegungsnummer: P32972
• Lagertemp.: −20°C
• Angaben zum Gen: mouse ... Tnfsf8(21949)

Beschreibung

Allgemeine Beschreibung

CD30 Ligand (CD30L) is a type II membrane glycoprotein of the tumor necrosis factor (TNF) superfamily. It is expressed on the cell surface of activated T cells, B cells, and monocytes. CD30L is also present in other cells, including mature dendritic cells, macrophages and mast cells. CD30L is also reffered to as Tnfsf8 (Tumor necrosis factor ligand superfamily member 8).

Immunogen

purified recombinant mouse CD30 ligand (amino acids 68-239) extracellular domain, expressed in NSO cells.

Anwendung

Anti-CD30 antibody produced in goat is suitable for indirect ELISA at a concentration of 0.5-1.0μg/mL and western blotting at a concentration of 0.1-0.2μg/mL.

Biochem./physiol. Wirkung

CD30L (CD30 ligand) along with CD30 is involved in activation and proliferation of T and B cells. They are also involved in the regulation of initial artherosclerosis development. CD30L/CD30 is crucial for maintenance and activation of IL (Interleukin)-17A-producing γδ T cells. CD30L/CD30 causes down-regulation of IL-2, resulting in Th17 differentiation of CD4⁺ T cells. CD30L helps in memory phenotype CD4⁺ T cells-mediated protection against infection with Listeria monocytogenes. CD30L/CD30 signaling is critical for Th1 response against Mycobacterium bovis bacillus Calmette-Guérin (BCG) infection. They are also linked to allergic rhinitis pathogenesis in mice. CD30L/CD30 signaling is involved in pathogenesis of inflammatory bowel diseases.

Physikalische Form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 13 - Non Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)