C1671

Chlorprothixen -hydrochlorid

• Synonym(e): 2-Chlor-9-(3-dimethylaminopropyliden)-thioxanthen -hydrochlorid
• Empirische Formel (Hill-System): C₁₈H₁₈ClNS · HCl
• CAS-Nummer: 6469-93-8
• Molekulargewicht: 352.32
• NACRES: NA.77
• PubChem Substance ID: 24278300
• UNSPSC Code: 12352200
• EC Number: 229-289-3
• MDL number: MFCD01941605
• Form: powder

Eigenschaften

• form: powder
• storage temp.: 2-8°C
• SMILES string: Cl.CN(C)CC\C=C1\c2ccccc2Sc3ccc(Cl)cc13
• InChI: 1S/C18H18ClNS.ClH/c1-20(2)11-5-7-14-15-6-3-4-8-17(15)21-18-10-9-13(19)12-16(14)18;/h3-4,6-10,12H,5,11H2,1-2H3;1H/b14-7-;
• InChI key: YWKRLOSRDGPEJR-KIUKIJHYSA-N
• Gene Information: human ... DRD2(1813), DRD3(1814), HTR2A(3356), HTR2C(3358)

Beschreibung

General description

Chlorprothixene is a neuroleptic drug, which belongs to thioxanthene group. It has anticholinergic effects. Chlorprothixene might be associated with obstructive jaundice and parkinsonism. It is used to treat psychosis.

Application

Chlorprothixene hydrochloride has been used to study its exposure effects on learning and memory of rats.

Biochem/physiol Actions

D₂ dopamine receptor antagonist; blocks a subset of GABA_A receptors in rat cortex that is also blocked by clozapine; thioxanthine antipsychotic.

Sicherheitshinweise

• pictograms: GHS06
• signalword: Danger
• hcodes: H301
• pcodes: P301 + P310
• Hazard Classifications: Acute Tox. 3 Oral
• Lagerklasse: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable