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C0884

Coenzym B12

≥97.0%

Synonym(e):

5′-Deoxyadenosylcobalamin, Adenosylcobalamin, Cobamamid, DMBC-Coenzym

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Über diesen Artikel

Empirische Formel (Hill-System):
C72H100CoN18O17P
CAS-Nummer:
Molekulargewicht:
1579.58
UNSPSC Code:
12352205
NACRES:
NA.79
PubChem Substance ID:
EC Number:
237-627-6
Beilstein/REAXYS Number:
4122932
MDL number:

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Unterstützung erhalten

Quality Level

assay

≥97.0%

form

powder and chunks

technique(s)

HPLC: suitable

color

red to very dark red, very dark red-brown

storage temp.

−20°C

SMILES string

CC(CNC(=O)CCC1(C)C(CC(N)=O)C2N([Co+]C[C@H]3O[C@@H]([C@H](O)[C@@H]3O)n4cnc5c(N)ncnc45)C1=C(C)C6=NC(=CC7=NC(=C(C)C8=NC2(C)C(C)(CC(N)=O)C8CCC(N)=O)C(C)(CC(N)=O)C7CCC(N)=O)C(C)(C)C6CCC(N)=O)OP([O-])(=O)O[C@H]9[C@@H](O)[C@H](O[C@@H]9CO)n%10cnc%11cc(C)c(C)cc%10%11

InChI

1S/C62H90N13O14P.C10H12N5O3.Co/c1-29-20-39-40(21-30(29)2)75(28-70-39)57-52(84)53(41(27-76)87-57)89-90(85,86)88-31(3)26-69-49(83)18-19-59(8)37(22-46(66)80)56-62(11)61(10,25-48(68)82)36(14-17-45(65)79)51(74-62)33(5)55-60(9,24-47(67)81)34(12-15-43(63)77)38(71-55)23-42-58(6,7)35(13-16-44(64)78)50(72-42)32(4)54(59)73-56;1-4-6(16)7(17)10(18-4)15-3-14-5-8(11)12-2-13-9(5)15;/h20-21,23,28,31,34-37,41,52-53,56-57,76,84H,12-19,22,24-27H2,1-11H3,(H15,63,64,65,66,67,68,69,71,72,73,74,77,78,79,80,81,82,83,85,86);2-4,6-7,10,16-17H,1H2,(H2,11,12,13);/q;;+2/p-2/t31?,34?,35?,36?,37?,41-,52-,53-,56?,57+,59?,60?,61?,62?;4-,6-,7-,10+;/m11./s1

InChI key

ZIHHMGTYZOSFRC-PMDPKNCCSA-L

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Dieser Artikel
M9756H8017C3607
technique(s)

HPLC: suitable

technique(s)

HPLC: suitable

technique(s)

HPLC: suitable

technique(s)

-

assay

≥97.0%

assay

≥97%

assay

≥95% (HPLC)

assay

96.0-102.0% dry basis

form

powder and chunks

form

powder

form

powder

form

powder

storage temp.

−20°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

color

red to very dark red, very dark red-brown

color

red to very dark red

color

red to brown

color

dark red

Quality Level

100

Quality Level

100

Quality Level

200

Quality Level

200

General description

Vitamin B12 Cobalamin bezieht sich auf eine Gruppe chemisch-verwandter kobalthaltiger Moleküle. Die physiologisch aktiven Formen von Vitamin B12 umfassen Methylcobalamin und Adenosylcobalamin, während Hydroxocobalamin (Vitamin B12a, OHCbl) und Cyanocobalamin (CNCbl) Speicher- und Darreichungsformen sind.

Application

Coenzym B12 wurde als Zusatz bei der Kultivierung von Plasmidvarianten in einem In-vivo-Assay von yvrC-lacZ-Fusionen verwendet.

Biochem/physiol Actions

Vitamin B12 Cobalamin ist an der DNA-Synthese und Fettsäuresynthese beteiligt. Es spielt auch eine wichtige Rolle als Coenzym bei der Umwandlung von mitochondrialem Methylmalonyl-Coenzym A zu Succinyl-Coenzym A.

Lagerklasse

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

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Besitzen Sie dieses Produkt bereits?

In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

Die Dokumentenbibliothek aufrufen

Coenzyme B12 riboswitches are widespread genetic control elements in prokaryotes
Nahvi A, et al.
Nucleic Acids Research, 32(1), 143-150 (2004)
Claire Chatelle et al.
ACS synthetic biology, 7(5), 1349-1358 (2018-04-11)
The ever-increasing complexity of synthetic gene networks and applications of synthetic biology requires precise and orthogonal gene expression systems. Of particular interest are systems responsive to light as they enable the control of gene expression dynamics with unprecedented resolution in
Radical carbon skeleton rearrangements: catalysis by coenzyme B12-dependent mutases.
Ruma Banerjee
Chemical reviews, 103(6), 2083-2094 (2003-06-12)
Denis Bucher et al.
Journal of the American Chemical Society, 134(3), 1591-1599 (2012-01-11)
Vitamin B(12) and its biologically active counterparts possess the only examples of carbon-cobalt bonds in living systems. The role of such motifs as radical reservoirs has potential application in future catalytic and electronic nanodevices. To fully understand radical generation in
Alla Peselis et al.
Nature structural & molecular biology, 19(11), 1182-1184 (2012-10-16)
Coenzyme B(12) has a key role in various enzymatic reactions and controls expression of bacterial genes through riboswitches. Here we report the crystal structure of the Symbiobacterium thermophilum B(12) riboswitch bound to its ligand adenosylcobalamin. The riboswitch forms a unique

Global Trade Item Number

SKUGTIN
C0884-25MG04061833452424
C0884-250MG04061833452400
C0884-100MG04061833269428
C0884-1G04061833452394

Questions

1–3 of 3 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  3. What is the pH stability of adenosylcobalamine?

    1 answer
    1. The pH stability of this product in solution has not been determined.

      Helpful?

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