B3183

Anti-BID antibody produced in rabbit

Cleavage site [59/60] specific, affinity isolated antibody, buffered aqueous glycerol solution

• UNSPSC Code: 12352203
• NACRES: NA.41
• MDL number: MFCD02095892

Eigenschaften

• Produktname: Anti-BID antibody produced in rabbit, Cleavage site [59/60] specific, affinity isolated antibody, buffered aqueous glycerol solution
• biological source: rabbit
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous glycerol solution
• mol wt: antigen 15 kDa
• species reactivity: mouse
• technique(s): microarray: suitable; western blot: suitable using mouse L929 cells treated with TNF-α
• UniProt accession no.: P70444
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Quality Level: 200
• Gene Information: mouse ... Bid(12122)

Beschreibung

Application

Polyclonal anti-BID antibody produced in rabbit is suitable for western blotting by using mouse L929 cells treated with TNF-α. It is also suitable for microarray.

Biochem/physiol Actions

The protein encoded by this gene is a member of the BCL-2 family of cell death regulators and is localized on to chromosome 22q11.2. BID is activated by caspase 8 in response to Fas/TNF-R1 receptor activation. Activated BID then translocated to mitochondria where it induces cytochrome c release, which in turn activates downstream caspases. It is a BH3 interacting death domain that heterodimerizes with either agonist BAX or antagonist BCL2. BID initiates apoptosis by binding to regulatory sites on prosurvival BCL2 proteins to directly neutralize their function. Additionally, BID interacts with cathepsins play an important role in the actions of Camptothecin on breast cancer cells.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Immunogen

synthetic peptide corresponding to N-terminal of cleavage site [59/60] of mouse BID.

Physical form

Supplied as a solution in Dulbecco′s phosphate buffered saline (without Mg²⁺ and Ca²⁺), pH 7.3, with 50% glycerol, 1.0 mg/ml BSA (IgG and protease free) and 0.05% sodium azide.

Sicherheitshinweise

• Lagerklasse: 10 - Combustible liquids