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Merck

A9789

Anisomycin

from Streptomyces griseolus, ≥98% (HPLC), solid, protein synthesis inhibitor

Synonym(e):

(2R,3S,4S)-2-(4-Methoxybenzyl)-3,4-pyrrolidindiol-3-acetat, Flagecidin

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5 MG

€ 80,80

25 MG

€ 234,00

100 MG

€ 699,00

€ 80,80

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Über diesen Artikel

Empirische Formel (Hill-System):
C14H19NO4
CAS-Nummer:
22862-76-6
Molekulargewicht:
265.30
NACRES:
NA.77
PubChem Substance ID:
24891496
UNSPSC Code:
12352200
EC Number:
245-269-7
MDL number:
MFCD00077650
Beilstein/REAXYS Number:
20705
Assay:
≥98% (HPLC)
Form:
solid

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Produktname

Anisomycin aus Streptomyces griseolus, ≥98% (HPLC), solid

assay

≥98% (HPLC)

form

solid

color

white to faint yellow

solubility

H2O: 2 mg/mL (Aqueous solutions are stable over a wide range of pH at room temperature.), DMSO: 20 mg/mL, methanol: 20 mg/mL

antibiotic activity spectrum

neoplastics

mode of action

protein synthesis | interferes

storage temp.

2-8°C

SMILES string

COc1ccc(C[C@H]2NC[C@H](O)[C@H]2OC(C)=O)cc1

InChI

1S/C14H19NO4/c1-9(16)19-14-12(15-8-13(14)17)7-10-3-5-11(18-2)6-4-10/h3-6,12-15,17H,7-8H2,1-2H3/t12-,13+,14+/m1/s1

InChI key

YKJYKKNCCRKFSL-RDBSUJKOSA-N

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Dieser Artikel
A5862S7809SML0918
Anisomycin from Streptomyces griseolus ≥98% (HPLC), solid

A9789

Anisomycin from Streptomyces griseolus

Anisomycin Ready Made Solution from Streptomyces griseolus, 10 mg/mL in DMSO

Sigma-Aldrich

A5862

Anisomycin

SKF-96365 ≥98% (HPLC), solid

S7809

SKF-96365

CID44216842 ≥98% (HPLC)

Sigma-Aldrich

SML0918

CID44216842

assay

≥98% (HPLC)

assay

-

assay

≥98% (HPLC)

assay

≥98% (HPLC)

form

solid

form

liquid

form

solid

form

powder

Quality Level

300

Quality Level

200

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

-

storage temp.

2-8°C

solubility

H2O: 2 mg/mL (Aqueous solutions are stable over a wide range of pH at room temperature.), methanol: 20 mg/mL, DMSO: 20 mg/mL

solubility

-

solubility

DMSO: >20 mg/mL, H2O: >20 mg/mL

solubility

DMSO: 20 mg/mL, clear

color

white to faint yellow

color

-

color

white

color

white to beige

Biochem/physiol Actions

Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. Reported to induce apoptosis in a variety of cells including promyelocytic leukemia cells, Jurkat cells, ventricular myocytes, and colon adenocarcinoma cells. Initiates intracellular signals and immediate early gene induction. Selective signaling agonist. Potent Jun-NH2 terminal kinase (JNK) agonist. Activates mitogen-activated protein (MAP) kinases (JNK/SAPK and p38/RK). Antiprotozoal agent.

Disclaimer

Hygroscopic

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301

Hazard Classifications

Acute Tox. 3 Oral

Lagerklasse

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number
0000510740
0000510740
0000453631
0000453631
0000442830

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J Daubriac et al.
Cell death and differentiation, 16(8), 1146-1155 (2009-04-04)
Pleural fluid accumulation is a frequent clinical observation in diffuse malignant pleural mesothelioma (MPM). The cytological analysis of pleural fluid often reveals the presence of free spheroid aggregates of malignant cells, giving rise to the question of the ability of
Puromycin reactivity does not accurately localize translation at the subcellular level
Enam , Syed Usman et al.
eLife, 9, e60303-e60303 (2020)
Verónica de la Fuente et al.
Scientific reports, 9(1), 12157-12157 (2019-08-23)
Memories are a product of the concerted activity of many brain areas. Deregulation of consolidation and reprocessing of mnemonic traces that encode fearful experiences might result in fear-related psychopathologies. Here, we assessed how pre-established memories change with experience, particularly the
Einar Ö Einarsson et al.
Learning & memory (Cold Spring Harbor, N.Y.), 19(10), 449-452 (2012-09-18)
It has been suggested that memories become more stable and less susceptible to the disruption of reconsolidation over weeks after learning. Here, we test this by targeting the anterior cingulate cortex (ACC) and test its involvement in the formation, consolidation
Shuangxi Li et al.
Proceedings of the National Academy of Sciences of the United States of America, 117(40), 25104-25115 (2020-09-23)
Maintaining the fidelity of nascent peptide chain (NP) synthesis is essential for proteome integrity and cellular health. Ribosome-associated quality control (RQC) serves to resolve stalled translation, during which untemplated Ala/Thr residues are added C terminally to stalled peptide, as shown
Alle zugehörigen Dokumente anzeigen

Global Trade Item Number

SKUGTIN
A9789-100MG04061833412442
A9789-25MG04061833412459
A9789-5MG04061833412466

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