A9451

Aristolochiasäure I Natriumsalz

Name: Aristolochiasäure I Natriumsalz
Brand: SIGMA
Price: 121 EUR

powder, ≥97%

Synonym(e):

Aristolochic acid sodium salt

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50 MG

€ 121,00

250 MG

€ 439,00

€ 121,00

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Über diesen Artikel

Empirische Formel (Hill-System):

C₁₇H₁₀NNaO₇

CAS-Nummer:

10190-99-5

Molekulargewicht:

363.25

NACRES:

NA.77

PubChem Substance ID:

24891454

UNSPSC Code:

12352202

EC Number:

233-463-4

MDL number:

MFCD00210760

Assay:

≥97%

Form:

powder

Solubility:

H₂O: 50 mg/mL

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Quality Level

200

assay

≥97%

form

powder

solubility

H₂O: 50 mg/mL

SMILES string

[Na+].COc1cccc2c1cc([N+]([O-])=O)c3c(cc4OCOc4c23)C([O-])=O

InChI

1S/C17H11NO7.Na/c1-23-12-4-2-3-8-9(12)5-11(18(21)22)14-10(17(19)20)6-13-16(15(8)14)25-7-24-13;/h2-6H,7H2,1H3,(H,19,20);/q;+1/p-1

InChI key

BQVOPWJSBBMGBR-UHFFFAOYSA-M

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Dieser Artikel	O2751	O0136	C4945
Sigma-Aldrich A9451 Aristolochic acid I sodium salt	Sigma-Aldrich O2751 Sodium oxamate	Sigma-Aldrich O0136 Sodium oxalate	Sigma-Aldrich C4945 Sodium cacodylate trihydrate
form powder	form powder	form powder	form powder
assay ≥97%	assay ≥98%	assay ≥99.0% (titration)	assay ≥98%
solubility H₂O: 50 mg/mL	solubility water: 50 mg/mL, clear, colorless	solubility -	solubility H₂O: 0.5 M, clear, colorless

Biochem/physiol Actions

Component of some Chinese herbal medicines, and responsible for their nephrotoxicity. Prodrug activated by reduction of the nitro group to an amine, which forms cytotoxic DNA adducts.

pictograms

GHS06,GHS08

signalword

Danger

hcodes

H301 + H311 + H331,H351

pcodes

P202 - P261 - P280 - P301 + P310 - P302 + P352 + P312 - P304 + P340 + P311

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Carc. 2

Lagerklasse

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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Cyclophilin D Promotes Acute, but Not Chronic, Kidney Injury in a Mouse Model of Aristolochic Acid Toxicity.

Khai Gene Leong et al.

Toxins, 13(10) (2021-10-23)

The plant-derived toxin, aristolochic acid (AA), is the cause of Chinese Herb Nephropathy and Balkan Nephropathy. Ingestion of high dose AA induces acute kidney injury, while chronic low dose ingestion leads to progressive kidney disease. Ingested AA is taken up

Upregulation of miR-382 contributes to renal fibrosis secondary to aristolochic acid-induced kidney injury via PTEN signaling pathway.

Xiaoyan Wang et al.

Cell death & disease, 11(8), 620-620 (2020-08-17)

Acute kidney injury (AKI) has a critical role in the development of chronic kidney disease (CKD). Building on our previous findings, we explored the role of miR-382 in facilitating the transition of AKI to CKD using the Aristolochic acid (AA)

Novel kidney dissociation protocol and image-based flow cytometry facilitate improved analysis of injured proximal tubules.

Marika Manolopoulou et al.

American journal of physiology. Renal physiology, 316(5), F847-F855 (2019-02-14)

Flow cytometry studies on injured kidney tubules are complicated by the low yield of nucleated single cells. Furthermore, cell-specific responses such as cell cycle dynamics in vivo have conventionally relied on indirect immunohistochemistry and proximal tubule markers that may be

Aristolochic acid mutational signature defines the low-risk subtype in upper tract urothelial carcinoma.

Huan Lu et al.

Theranostics, 10(10), 4323-4333 (2020-04-16)

Rationale: Dietary exposure to aristolochic acids and similar compounds (collectively, AA) is a significant risk factor for nephropathy and subsequent upper tract urothelial carcinoma (UTUC). East Asian populations, who have a high prevalence of UTUC, have an unusual genome-wide AA-induced

Drosophila TRPA1 channel mediates chemical avoidance in gustatory receptor neurons.

Sang Hoon Kim et al.

Proceedings of the National Academy of Sciences of the United States of America, 107(18), 8440-8445 (2010-04-21)

Mammalian sweet, bitter, and umami taste is mediated by a single transduction pathway that includes a phospholipase C (PLC)beta and one cation channel, TRPM5. However, in insects such as the fruit fly, Drosophila melanogaster, it is unclear whether different tastants

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Global Trade Item Number

SKU	GTIN
A9451-50MG	04061833616499
A9451-250MG	04061833616482

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Aristolochiasäure I Natriumsalz