A8344

Anti-ARC, C-Terminal antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

• Synonym(e): Anti-Apoptosis Repressor with CARD
• MDL-Nummer: MFCD02095862
• UNSPSC-Code: 12352203

Eigenschaften

• Biologische Quelle: rabbit
• Konjugat: unconjugated
• Antikörperform: affinity isolated antibody
• Antikörper-Produkttyp: primary antibodies
• Klon: polyclonal
• Form: buffered aqueous solution
• Mol-Gew.: antigen 22 kDa
• Speziesreaktivität: human
• Methode(n): microarray: suitable; western blot: 1:1,000 using HeLa cell extract
• UniProt-Hinterlegungsnummer: O60936
• Versandbedingung: dry ice
• Lagertemp.: −20°C
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... NOL3(8996)

Beschreibung

Allgemeine Beschreibung

ARC is part of the activity regulated cytoskeleton-associated protein family. It is involved in endocytosis of AMPA receptors and formation of long-term memory. It is found expressed in the cytoplasma of neuronal dendrites.

ARC protein contains an N-terminal CARD that has homology to the CARDs present in Apaf-1 and RAIDD. It binds to and inhibits the activity of caspase 8. It also binds to caspase 9 and to Ced-3. It inhibits apoptosis induced by death receptors that require caspase 8 activation.

Rabbit Anti-ARC, C-Terminal antibody binds to amino acids 191-208 of human ARC.

Immunogen

synthetic peptide corresponding to amino acids 191-208 of human ARC (apoptosis repressor with CARD).

Anwendung

Rabbit Anti-ARC, C-Terminal antibody can be used for western blot (1:1,000) and microarray analyses.

Physikalische Form

Solution in phosphate buffered saline containing 0.02% sodium azide.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.