A7845

ATPO

solid

• Synonym(e): (R,S)-2-Amino-3-[5-tert-butyl-3-(phosphonomethoxy)-4-isoxazolyl]propionic acid
• Empirische Formel (Hill-System): C₁₁H₁₉N₂O₇P
• CAS-Nummer: 252930-37-3
• Molekulargewicht: 322.25
• UNSPSC Code: 12352200
• PubChem Substance ID: 24278239
• MDL number: MFCD03452828

Eigenschaften

• form: solid
• solubility: 1 M NaOH: soluble 7 mg/mL, DMSO: insoluble, H₂O: insoluble
• SMILES string: CC(C)(C)c1onc(OCP(O)(O)=O)c1CC(N)C(O)=O
• InChI: 1S/C11H19N2O7P/c1-11(2,3)8-6(4-7(12)10(14)15)9(13-20-8)19-5-21(16,17)18/h7H,4-5,12H2,1-3H3,(H,14,15)(H2,16,17,18)
• InChI key: AGSOOCUNMTYPSE-UHFFFAOYSA-N
• Gene Information: human ... GRIA1(2890), GRIA2(2891), GRIA3(2892), GRIA4(2893) ; rat ... Gria1(50592), Grik1(29559), Grin2a(24409)

Beschreibung

Application

The phosphono amino acid, (RS)-2-amino-3-[5-tert-butyl-3-(phosphonomethoxy)-4-isoxazolyl+ ++]propio nic acid (ATPO) is a competitive antagonist at GluR1-4 (AMPA-preferring) receptors. ATPO is a structural hybrid between the NMDA antagonist (RS)-2-amino-7-phosphonoheptanoic acid (AP7) and the AMPA/GluR5 agonist, (RS)-2-amino-3-(5-tert-butyl-3-hydroxy-4-isoxazolyl)propionic acid (ATPA).

Biochem/physiol Actions

Competitive antagonist at GluR1-4 (AMPA-preferring) receptors.

Sicherheitshinweise

• Lagerklasse: 13 - Non Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)