A7230

Alinidine

≥98% (HPLC), solid

• Synonym(e): N-(2,6-Dichlorophenyl)-4,5-dihydro-N-2-propenyl-1H-imidazol-2-amine, ST-567
• Empirische Formel (Hill-System): C₁₂H₁₃Cl₂N₃
• CAS-Nummer: 33178-86-8
• Molekulargewicht: 270.16
• UNSPSC Code: 12352200
• PubChem Substance ID: 24891193
• MDL number: MFCD00864689

Eigenschaften

• assay: ≥98% (HPLC)
• form: solid
• storage condition: under inert gas
• color: off-white
• solubility: DMSO: >10 mg/mL
• storage temp.: 2-8°C
• SMILES string: Clc1cccc(Cl)c1N(CC=C)C2=NCCN2

Beschreibung

Biochem/physiol Actions

Alinidine is an HCN Channel blocker of neuronal I_h, related cardiac I_f channels and ATP-sensitive K_ir channels. It is an analog of clonidine; bradycardic and antiarrhythmic agent (sinus tachyarrhythmias). Alinidine affects physiological markers in conscious dogs. Alinidine in four intravenous (i.v.) injections of 0.5, 0.5, 1, and 2 mg/kg, decreased sinus rate (< or = 43%) and ventricular rate (< or = 44%), but increased atrial rate (< or = 31%). It lengthened CSRT (< or = 71%) at the two highest doses and increased AERP (< or = 33%) and decreased WP (< or = 33%) at all doses. Alinidine did not modify mean blood pressure at any dose in either group. These results indicate that alinidine exhibits electrophysiologic effects in conscious dogs that reflect the marked antiarrhythmic potential of this agent, apart from its assumed antiischemic properties.

Alinidine is an HCN channel blocker; Blocker of neuronal I_h, related cardiac I_f channels and ATP-sensitive K_ir channels. Analog of clonidine; bradycardic and antiarrhythmic agent (sinus tachyarrhythmias).

Disclaimer

Air-sensitive

Sicherheitshinweise

• pictograms: GHS07
• signalword: Warning
• hcodes: H302,H315,H319,H335
• pcodes: P301 + P312 + P330 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Lagerklasse: 13 - Non Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Faceshields, Gloves