A4687
Amiprilose hydrochloride
Synonym(e):
1,2-O-Isopropylidene-3-O-[3′-(N,N-dimethylamino)propyl]-α-D-glucofuranose hydrochloride
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Empirische Formel (Hill-System):
C14H27NO6 · HCl
CAS-Nummer:
Molekulargewicht:
341.83
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
Technischer Dienst
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Unterstützung erhaltenstorage temp.
2-8°C
SMILES string
Cl[H].[H][C@@]1(O[C@@H]2OC(C)(C)O[C@@H]2[C@H]1OCCCN(C)C)[C@H](O)CO
Biochem/physiol Actions
A synthetic carbohydrate shown to be a immunomodulator and anti-viral agent. Used as therapeutic agent in inflammatory arthritis. Regulatory effects on cytokines have been demonstrated in vitro. In vivo treatment of mice results in modulation of eicosanoid synthesis in part through the regulation of PLA2 activity.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Lagerklasse
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
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C E Brinckerhoff
Agents and actions, 30(3-4), 322-328 (1990-06-01)
Amiprilose hydrochloride, a modified hexose sugar effectively decreases proliferation of human skin and synovial fibroblasts and of rabbit synovial fibroblasts. It also decreases production of the inflammatory mediator prostaglandin E2 (PGE2) by these cells. Cell proliferation, measured by incorporation of
D H Campen et al.
Arthritis and rheumatism, 31(11), 1358-1364 (1988-11-01)
Levels of interleukin-2 receptors (IL-2R), as measured by a double-antibody "sandwich" enzyme-linked immunosorbent assay technique, were markedly elevated in the serum of patients with systemic lupus erythematosus, rheumatoid arthritis, and bacterial endocarditis, but not in patients with acute gout. Serum
W G Riskin et al.
Annals of internal medicine, 111(6), 455-465 (1989-09-15)
To assess the safety and efficacy of amiprilose hydrochloride (HCl), a novel synthetic carbohydrate with anti-inflammatory and immunomodulatory properties, in patients with rheumatoid arthritis. Prospective, multicenter, randomized, parallel group, double-blind placebo-controlled 12-week trial. Two hundred and one functional class I