A3537

5-Aminosalicylsäure

powder, ≥99%

• Synonym(e): 5-AS, 5-Amino-2-hydroxy-benzoesäure, Mesalazin
• Lineare Formel: H₂NC₆H₃-2-(OH)CO₂H
• CAS-Nummer: 89-57-6
• Molekulargewicht: 153.14
• NACRES: NA.83
• PubChem Substance ID: 24890780
• UNSPSC Code: 12352204
• EC Number: 201-919-1
• MDL number: MFCD00007877
• Beilstein/REAXYS Number: 2090421

Eigenschaften

• Produktname: 5-Aminosalicylsäure, ≥99%
• Quality Segment: 200
• assay: ≥99%
• form: powder
• color: off-white to gray
• mp: 275-280 °C (dec.) (lit.)
• solubility: 1 M HCl: 50 mg/mL, clear, yellow to brown
• storage temp.: 2-8°C
• SMILES string: Nc1ccc(O)c(c1)C(O)=O
• InChI: 1S/C7H7NO3/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3,9H,8H2,(H,10,11)
• InChI key: KBOPZPXVLCULAV-UHFFFAOYSA-N
• Gene Information: human ... ALOX5(240), PPARG(5468), PTGS1(5742), PTGS2(5743)

Beschreibung

Application

5-Aminosalicylsäure ist ein Peroxidasesubstrat, geeignet für den Einsatz in ELISA-Verfahren. Dieses Substrat bildet ein lösliches braunes Endprodukt, das spektralphotometrisch bei 450 nm ausgelesen werden kann. Die Reaktion kann mit 3 N NaOH gestoppt und bei 550 nm ausgelesen werden.

5-Aminosalicylic acid (5-ASA) has been used:

• to synthesize 5-formyl-aminosalicylate-inulin to quantify its release during in vitro digestion and fermentation and compare the in vitro fermentation properties of the conjugated inulin to native inulin
• in cell adhesion assay to study its effects on E-cadherin glycosylation and membranous turnover[1]
• to evaluate its effects on the neutrophilic inflammation index (NII) phenotype to study the effectiveness of the high cholesterol diet-gut inflammation (HCD-GI) platform[2]

Biochem/physiol Actions

5-Aminosalicylic acid (5-ASA) is a first-line medicine, used to treat inflammatory bowel diseases like ulcerative colitis (UC).[3][4] It has a high-efficiency rate in maintenance and induction of remission.[5] 5-ASA is an active component of sulfasalazine and also consists of the carbohydrate polymer, inulin.[3] It might exhibit anti-oxidant activity to lessen tissue injury. 5-ASA is vital for the prevention of T cell activation and proliferation.[5] It negatively regulates cyclooxygenase and lipoxygenase pathways and lowers the formation of prostaglandins and leukotrienes.[5] 5-ASA stimulates the membranous expression of E-cadherin and boosts intercellular adhesion.[1]

Sicherheitshinweise

• pictograms: GHS07
• signalword: Warning
• hcodes: H315,H317,H319,H335
• pcodes: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
• target_organs: Respiratory system
• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 2
• flash_point_f: No data available
• flash_point_c: No data available
• ppe: dust mask type N95 (US), Eyeshields, Gloves